Caenorhabditis elegans mounts a p38 MAPK pathway‐mediated defence to Cutibacterium acnes infection

Caenorhabditis elegans mounts a p38 MAPK pathway‐mediated defence to Cutibacterium acnes infection

Cutibacterium acnes is capable of inducing inflammation in acne and can lead to a chronic prostatic infection. The diverse pathogenicity among different strains of C. acnes has been presented, but simple appropriate animal models for the evaluation of this bacterium are lacking. In this study, the n...

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Veröffentlicht in:Cellular microbiology 2020-10, Vol.22 (10), p.e13234-n/a
Hauptverfasser: Huang, Xiaowen, Pan, Wen, Kim, Wooseong, White, Alexis, Li, Silei, Li, Huiying, Lee, Kiho, Fuchs, Beth Burgwyn, Zeng, Kang, Mylonakis, Eleftherios
Format: Artikel
Sprache:eng
Schlagworte:
Acne
Animal models
Antibiotics
Caenorhabditis elegans
Chronic infection
Culture media
Cutibacterium acnes
C‐type lectins
immune defence
Immune response
infection model
Infections
Innate immunity
Invertebrates
Kinases
Lectins
Liquid culture
MAP kinase
Mutants
Nematodes
p38 MAPK pathway
Pathogenicity
Pathogens
Protein kinase
Survival
Virulence
Worms
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Zusammenfassung:Cutibacterium acnes is capable of inducing inflammation in acne and can lead to a chronic prostatic infection. The diverse pathogenicity among different strains of C. acnes has been presented, but simple appropriate animal models for the evaluation of this bacterium are lacking. In this study, the nematode Caenorhabditis elegans was used as an invertebrate infection model. We revealed that C. acnes type strain ATCC 6919 caused lethal infections to C. elegans in solid and liquid culture media (p 
ISSN:1462-5814
1462-5822
DOI:10.1111/cmi.13234