Prognostic value of log odds of positive lymph nodes in patients with resectable oral squamous cell carcinoma

•Traditional pN does not consider lymph nodes as a whole.•Log odds of positive lymph nodes (LODDS) is superior to pN and lymph-node ratio in predicting overall survival.•LODDS is the best predictor in patients without positive lymph nodes and adequate neck dissection. Log odds of positive lymph node...

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Veröffentlicht in:Oral oncology 2020-09, Vol.108, p.104709-104709, Article 104709
Hauptverfasser: Jin, Wanyong, Zhu, Zaiou, Wu, Yuanyuan, Ding, Xu, Wu, Heming, Song, Xiaomeng, Wu, Yunong
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Sprache:eng
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Zusammenfassung:•Traditional pN does not consider lymph nodes as a whole.•Log odds of positive lymph nodes (LODDS) is superior to pN and lymph-node ratio in predicting overall survival.•LODDS is the best predictor in patients without positive lymph nodes and adequate neck dissection. Log odds of positive lymph nodes (LODDS) was reported to be significantly associated with prognosis in several malignant tumors. However, few are the studies on the correlation between LODDS and overall survival (OS) in patients with oral squamous cell carcinoma (OSCC). A retrospective study including 233 patients with OSCC during 2009 to 2013 was conducted. We probed the correlation between clinicopathological factor, LODDS, lymph node ratio (LNR), pN and OS. The potential prognostic factor and the independent factor were calculated using univariate analysis and multivariate analysis respectively. The goodness of fit and the discriminability was analyzed with Somer’s D value, Nagelkerke R2 index, and Akaike information criterion (AIC). Kaplan-Meier survival curve of OS was contrasted by log-rank test in LODDS, LNR and pN, respectively. According to the X-tile, the cut-off values are −1.491 and −0.763 for LODDS, 0.024 and 0.133 for LNR. LODDS, LNR and pN were significantly correlated with OS by univariate analysis (P 
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2020.104709