Caffeine improves various aspects of athletic performance in adolescents independent of their 163 C > A CYP1A2 genotypes
Purpose The purpose of this study was to investigate whether variations in 163 C > A CYP1A2 genotypes (rs 762 551) (AA, AC, and CC) modify the ergogenic effects of caffeine (CAF) on strength, power, muscular endurance, agility, and endurance in adolescent athletes. Methods One hundred adolescents...
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| Veröffentlicht in: | Scandinavian journal of medicine & science in sports 2020-10, Vol.30 (10), p.1869-1877 |
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| container_title | Scandinavian journal of medicine & science in sports |
| container_volume | 30 |
| creator | Spineli, Higor Pinto, Maryssa P. Dos Santos, Bruna P. Lima‐Silva, Adriano E. Bertuzzi, Romulo Gitaí, Daniel L. G. Araujo, Gustavo G. |
| description | Purpose
The purpose of this study was to investigate whether variations in 163 C > A CYP1A2 genotypes (rs 762 551) (AA, AC, and CC) modify the ergogenic effects of caffeine (CAF) on strength, power, muscular endurance, agility, and endurance in adolescent athletes.
Methods
One hundred adolescents (age = 15 ± 2 years) were recruited. Participants ingested CAF (6 mg.kg−1) or placebo (PLA, 300 mg of cellulose) 1 hour before performing a sequence of physical tests: handgrip strength, vertical jumps, agility test, sit‐ups, push‐ups, and the Yo‐Yo intermittent recovery test level 1 (Yo‐Yo IR1).
Results
Compared to PLA, CAF enhanced (P .05). When present, the ergogenic effect of CAF was not dependent of genotype.
Conclusion
CAF improves muscular endurance and aerobic performance in adolescent athletes, regardless of their 163 C > A CYP1A2 genotype. |
| doi_str_mv | 10.1111/sms.13749 |
| format | Article |
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The purpose of this study was to investigate whether variations in 163 C > A CYP1A2 genotypes (rs 762 551) (AA, AC, and CC) modify the ergogenic effects of caffeine (CAF) on strength, power, muscular endurance, agility, and endurance in adolescent athletes.
Methods
One hundred adolescents (age = 15 ± 2 years) were recruited. Participants ingested CAF (6 mg.kg−1) or placebo (PLA, 300 mg of cellulose) 1 hour before performing a sequence of physical tests: handgrip strength, vertical jumps, agility test, sit‐ups, push‐ups, and the Yo‐Yo intermittent recovery test level 1 (Yo‐Yo IR1).
Results
Compared to PLA, CAF enhanced (P < .05) sit‐up (CAF = 37 ± 9; PLA = 35 ± 8 repetitions) and push‐up repetitions (CAF = 26 ± 11; PLA = 24 ± 11 repetitions), and increased distance covered in Yo‐Yo IR1 test (CAF = 1010.4 ± 378.9; PLA = 903.2 ± 325.7 m). There was no influence of CAF on handgrip strength (CAF = 35.1 ± 8.9; PLA = 33.7 ± 8.7 kgf), countermovement jump height (CAF = 49.3 ± 12.6; PLA = 47.9 ± 13.8 cm), spike jump height (CAF = 54.2 ± 13.6; PLA = 52.9 ± 14.5 cm), and time in agility test (CAF = 15.8 ± 1.1; PLA = 15.9 ± 1.3 s, P > .05). When present, the ergogenic effect of CAF was not dependent of genotype.
Conclusion
CAF improves muscular endurance and aerobic performance in adolescent athletes, regardless of their 163 C > A CYP1A2 genotype.</description><identifier>ISSN: 0905-7188</identifier><identifier>EISSN: 1600-0838</identifier><identifier>DOI: 10.1111/sms.13749</identifier><identifier>PMID: 32538495</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Athletic Performance - physiology ; Caffeine ; Caffeine - pharmacology ; Central Nervous System Stimulants - pharmacology ; Cross-Over Studies ; CYP ; Cytochrome P-450 CYP1A2 - blood ; Cytochrome P-450 CYP1A2 - genetics ; Double-Blind Method ; Endurance ; ergogenic effects ; exercise ; Exercise - physiology ; genetic polymorphism ; Genotype ; Hand Strength - physiology ; Humans ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - physiology ; Placebos - pharmacology ; Polymorphism, Genetic ; Teenagers</subject><ispartof>Scandinavian journal of medicine & science in sports, 2020-10, Vol.30 (10), p.1869-1877</ispartof><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-6960b3f18a0e192ea6df37e02dd47a29e8fe1ed297aac82cd1e127ce1f8707023</citedby><cites>FETCH-LOGICAL-c3539-6960b3f18a0e192ea6df37e02dd47a29e8fe1ed297aac82cd1e127ce1f8707023</cites><orcidid>0000-0003-2840-865X ; 0000-0001-6992-8817 ; 0000-0002-3694-9977 ; 0000-0001-7056-2373 ; 0000-0002-0407-9620 ; 0000-0002-0613-5104 ; 0000-0003-4609-069X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fsms.13749$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fsms.13749$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32538495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spineli, Higor</creatorcontrib><creatorcontrib>Pinto, Maryssa P.</creatorcontrib><creatorcontrib>Dos Santos, Bruna P.</creatorcontrib><creatorcontrib>Lima‐Silva, Adriano E.</creatorcontrib><creatorcontrib>Bertuzzi, Romulo</creatorcontrib><creatorcontrib>Gitaí, Daniel L. G.</creatorcontrib><creatorcontrib>Araujo, Gustavo G.</creatorcontrib><title>Caffeine improves various aspects of athletic performance in adolescents independent of their 163 C > A CYP1A2 genotypes</title><title>Scandinavian journal of medicine & science in sports</title><addtitle>Scand J Med Sci Sports</addtitle><description>Purpose
The purpose of this study was to investigate whether variations in 163 C > A CYP1A2 genotypes (rs 762 551) (AA, AC, and CC) modify the ergogenic effects of caffeine (CAF) on strength, power, muscular endurance, agility, and endurance in adolescent athletes.
Methods
One hundred adolescents (age = 15 ± 2 years) were recruited. Participants ingested CAF (6 mg.kg−1) or placebo (PLA, 300 mg of cellulose) 1 hour before performing a sequence of physical tests: handgrip strength, vertical jumps, agility test, sit‐ups, push‐ups, and the Yo‐Yo intermittent recovery test level 1 (Yo‐Yo IR1).
Results
Compared to PLA, CAF enhanced (P < .05) sit‐up (CAF = 37 ± 9; PLA = 35 ± 8 repetitions) and push‐up repetitions (CAF = 26 ± 11; PLA = 24 ± 11 repetitions), and increased distance covered in Yo‐Yo IR1 test (CAF = 1010.4 ± 378.9; PLA = 903.2 ± 325.7 m). There was no influence of CAF on handgrip strength (CAF = 35.1 ± 8.9; PLA = 33.7 ± 8.7 kgf), countermovement jump height (CAF = 49.3 ± 12.6; PLA = 47.9 ± 13.8 cm), spike jump height (CAF = 54.2 ± 13.6; PLA = 52.9 ± 14.5 cm), and time in agility test (CAF = 15.8 ± 1.1; PLA = 15.9 ± 1.3 s, P > .05). When present, the ergogenic effect of CAF was not dependent of genotype.
Conclusion
CAF improves muscular endurance and aerobic performance in adolescent athletes, regardless of their 163 C > A CYP1A2 genotype.</description><subject>Adolescent</subject><subject>Athletic Performance - physiology</subject><subject>Caffeine</subject><subject>Caffeine - pharmacology</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Cross-Over Studies</subject><subject>CYP</subject><subject>Cytochrome P-450 CYP1A2 - blood</subject><subject>Cytochrome P-450 CYP1A2 - genetics</subject><subject>Double-Blind Method</subject><subject>Endurance</subject><subject>ergogenic effects</subject><subject>exercise</subject><subject>Exercise - physiology</subject><subject>genetic polymorphism</subject><subject>Genotype</subject><subject>Hand Strength - physiology</subject><subject>Humans</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - physiology</subject><subject>Placebos - pharmacology</subject><subject>Polymorphism, Genetic</subject><subject>Teenagers</subject><issn>0905-7188</issn><issn>1600-0838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10cFqFTEUBuAgir2tLnwBCbixi2lzkswk2QiXQVuholBduBrSzIlNmcmMydzK7dP0WfpkTb3VhWAWyeY7Pzn8hLwCdgTlHOcxH4FQ0jwhK2gYq5gW-ilZMcPqSoHWe2Q_5yvGQBlZPyd7gtdCS1OvyE1rvccQkYZxTtM1ZnptU5g2mdo8o1synTy1y-WAS3B0xuSnNNroykCktp8GzA5jYSH2OGO54vIwslxiSBQaQdu723d3t2vafv8Ca05_YJyW7Yz5BXnm7ZDx5eN7QL59eP-1Pa3OPp98bNdnlRO1MFVjGnYhPGjLEAxH2_ReKGS876Wy3KD2CNhzo6x1mrseELhyCF4rphgXB-TtLrfs93ODeenGUP48DDZi2bPjEoQxDRhT6Jt_6NW0SbH8rijJGyMbKYs63CmXppwT-m5OYbRp2wHrHgrpSiHd70KKff2YuLkYsf8r_zRQwPEO_AoDbv-f1J1_Ot9F3gPlAZY0</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Spineli, Higor</creator><creator>Pinto, Maryssa P.</creator><creator>Dos Santos, Bruna P.</creator><creator>Lima‐Silva, Adriano E.</creator><creator>Bertuzzi, Romulo</creator><creator>Gitaí, Daniel L. G.</creator><creator>Araujo, Gustavo G.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2840-865X</orcidid><orcidid>https://orcid.org/0000-0001-6992-8817</orcidid><orcidid>https://orcid.org/0000-0002-3694-9977</orcidid><orcidid>https://orcid.org/0000-0001-7056-2373</orcidid><orcidid>https://orcid.org/0000-0002-0407-9620</orcidid><orcidid>https://orcid.org/0000-0002-0613-5104</orcidid><orcidid>https://orcid.org/0000-0003-4609-069X</orcidid></search><sort><creationdate>202010</creationdate><title>Caffeine improves various aspects of athletic performance in adolescents independent of their 163 C > A CYP1A2 genotypes</title><author>Spineli, Higor ; Pinto, Maryssa P. ; Dos Santos, Bruna P. ; Lima‐Silva, Adriano E. ; Bertuzzi, Romulo ; Gitaí, Daniel L. G. ; Araujo, Gustavo G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-6960b3f18a0e192ea6df37e02dd47a29e8fe1ed297aac82cd1e127ce1f8707023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Athletic Performance - physiology</topic><topic>Caffeine</topic><topic>Caffeine - pharmacology</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Cross-Over Studies</topic><topic>CYP</topic><topic>Cytochrome P-450 CYP1A2 - blood</topic><topic>Cytochrome P-450 CYP1A2 - genetics</topic><topic>Double-Blind Method</topic><topic>Endurance</topic><topic>ergogenic effects</topic><topic>exercise</topic><topic>Exercise - physiology</topic><topic>genetic polymorphism</topic><topic>Genotype</topic><topic>Hand Strength - physiology</topic><topic>Humans</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - physiology</topic><topic>Placebos - pharmacology</topic><topic>Polymorphism, Genetic</topic><topic>Teenagers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spineli, Higor</creatorcontrib><creatorcontrib>Pinto, Maryssa P.</creatorcontrib><creatorcontrib>Dos Santos, Bruna P.</creatorcontrib><creatorcontrib>Lima‐Silva, Adriano E.</creatorcontrib><creatorcontrib>Bertuzzi, Romulo</creatorcontrib><creatorcontrib>Gitaí, Daniel L. G.</creatorcontrib><creatorcontrib>Araujo, Gustavo G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of medicine & science in sports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spineli, Higor</au><au>Pinto, Maryssa P.</au><au>Dos Santos, Bruna P.</au><au>Lima‐Silva, Adriano E.</au><au>Bertuzzi, Romulo</au><au>Gitaí, Daniel L. G.</au><au>Araujo, Gustavo G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Caffeine improves various aspects of athletic performance in adolescents independent of their 163 C > A CYP1A2 genotypes</atitle><jtitle>Scandinavian journal of medicine & science in sports</jtitle><addtitle>Scand J Med Sci Sports</addtitle><date>2020-10</date><risdate>2020</risdate><volume>30</volume><issue>10</issue><spage>1869</spage><epage>1877</epage><pages>1869-1877</pages><issn>0905-7188</issn><eissn>1600-0838</eissn><abstract>Purpose
The purpose of this study was to investigate whether variations in 163 C > A CYP1A2 genotypes (rs 762 551) (AA, AC, and CC) modify the ergogenic effects of caffeine (CAF) on strength, power, muscular endurance, agility, and endurance in adolescent athletes.
Methods
One hundred adolescents (age = 15 ± 2 years) were recruited. Participants ingested CAF (6 mg.kg−1) or placebo (PLA, 300 mg of cellulose) 1 hour before performing a sequence of physical tests: handgrip strength, vertical jumps, agility test, sit‐ups, push‐ups, and the Yo‐Yo intermittent recovery test level 1 (Yo‐Yo IR1).
Results
Compared to PLA, CAF enhanced (P < .05) sit‐up (CAF = 37 ± 9; PLA = 35 ± 8 repetitions) and push‐up repetitions (CAF = 26 ± 11; PLA = 24 ± 11 repetitions), and increased distance covered in Yo‐Yo IR1 test (CAF = 1010.4 ± 378.9; PLA = 903.2 ± 325.7 m). There was no influence of CAF on handgrip strength (CAF = 35.1 ± 8.9; PLA = 33.7 ± 8.7 kgf), countermovement jump height (CAF = 49.3 ± 12.6; PLA = 47.9 ± 13.8 cm), spike jump height (CAF = 54.2 ± 13.6; PLA = 52.9 ± 14.5 cm), and time in agility test (CAF = 15.8 ± 1.1; PLA = 15.9 ± 1.3 s, P > .05). When present, the ergogenic effect of CAF was not dependent of genotype.
Conclusion
CAF improves muscular endurance and aerobic performance in adolescent athletes, regardless of their 163 C > A CYP1A2 genotype.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>32538495</pmid><doi>10.1111/sms.13749</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2840-865X</orcidid><orcidid>https://orcid.org/0000-0001-6992-8817</orcidid><orcidid>https://orcid.org/0000-0002-3694-9977</orcidid><orcidid>https://orcid.org/0000-0001-7056-2373</orcidid><orcidid>https://orcid.org/0000-0002-0407-9620</orcidid><orcidid>https://orcid.org/0000-0002-0613-5104</orcidid><orcidid>https://orcid.org/0000-0003-4609-069X</orcidid></addata></record> |
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| ispartof | Scandinavian journal of medicine & science in sports, 2020-10, Vol.30 (10), p.1869-1877 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Athletic Performance - physiology Caffeine Caffeine - pharmacology Central Nervous System Stimulants - pharmacology Cross-Over Studies CYP Cytochrome P-450 CYP1A2 - blood Cytochrome P-450 CYP1A2 - genetics Double-Blind Method Endurance ergogenic effects exercise Exercise - physiology genetic polymorphism Genotype Hand Strength - physiology Humans Muscle, Skeletal - drug effects Muscle, Skeletal - physiology Placebos - pharmacology Polymorphism, Genetic Teenagers |
| title | Caffeine improves various aspects of athletic performance in adolescents independent of their 163 C > A CYP1A2 genotypes |
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