Caffeine improves various aspects of athletic performance in adolescents independent of their 163 C > A CYP1A2 genotypes

Purpose The purpose of this study was to investigate whether variations in 163 C > A CYP1A2 genotypes (rs 762 551) (AA, AC, and CC) modify the ergogenic effects of caffeine (CAF) on strength, power, muscular endurance, agility, and endurance in adolescent athletes. Methods One hundred adolescents (age = 15 ± 2 years) were recruited. Participants ingested CAF (6 mg.kg−1) or placebo (PLA, 300 mg of cellulose) 1 hour before performing a sequence of physical tests: handgrip strength, vertical jumps, agility test, sit‐ups, push‐ups, and the Yo‐Yo intermittent recovery test level 1 (Yo‐Yo IR1). Results Compared to PLA, CAF enhanced (P .05). When present, the ergogenic effect of CAF was not dependent of genotype. Conclusion CAF improves muscular endurance and aerobic performance in adolescent athletes, regardless of their 163 C > A CYP1A2 genotype.