Is Albumin Predictor of Mortality in COVID-19?

Is Albumin Predictor of Mortality in COVID-19?

Coronavirus 2019 (COVID-19) is a pandemic associated with a high risk of mortality. Human serum albumin (HSA) is an acute phase reactant with antioxidant property; however, its behavior and impact on survival in COVID-19 patients have never been studied so far. Among 319 COVID-19 patients followed u...

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Veröffentlicht in:Antioxidants & redox signaling 2021-07, Vol.35 (2), p.139-142
Hauptverfasser: Violi, Francesco, Cangemi, Roberto, Romiti, Giulio Francesco, Ceccarelli, Giancarlo, Oliva, Alessandra, Alessandri, Francesco, Pirro, Matteo, Pignatelli, Pasquale, Lichtner, Miriam, Carraro, Anna, Cipollone, Francesco, D'ardes, Damiano, Pugliese, Francesco, Mastroianni, Claudio Maria
Format: Artikel
Sprache:eng
Schlagworte:
Albumin
Antioxidants
C-reactive protein
Chronic obstructive pulmonary disease
Confidence intervals
Congestive heart failure
Coronary artery disease
Coronaviruses
COVID-19
Dimers
Heart failure
Human serum albumin
Lung diseases
Mortality
Obstructive lung disease
Pandemics
Regression analysis
Serum albumin
Statistical analysis
Viral diseases
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Zusammenfassung:Coronavirus 2019 (COVID-19) is a pandemic associated with a high risk of mortality. Human serum albumin (HSA) is an acute phase reactant with antioxidant property; however, its behavior and impact on survival in COVID-19 patients have never been studied so far. Among 319 COVID-19 patients followed up for a median of 19 days, 64 died. Compared with survivors, nonsurvivors had more prevalence of intensive care unit (ICU) admission, chronic obstructive pulmonary disease (COPD), heart failure, elevated levels of D-dimer, high-sensitivity C reactive protein (hs-CRP) and troponins, and lower values of albumin. At the Cox regression analysis, albumin (hazard ratio [HR]: 0.38, 95% confidence interval [CI]: 0.23–0.63, p 
ISSN:1523-0864
1557-7716
DOI:10.1089/ars.2020.8142