COVID-19: Pathogenesis of a multi-faceted disease

SARS-CoV-2 infection, named COVID-19, can lead to a dysregulated immune response and abnormal coagulation responsible for a viral sepsis. In this review, we specify physiopathological mechanisms of each phase of COVID-19 - viral, immune and pro-thrombotic - notably because they involve different tre...

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Veröffentlicht in:	La revue de medecine interne 2020-06, Vol.41 (6), p.375-389
Hauptverfasser:	Bonny, Maillard, A., Mousseaux, C., Placais, L., Richier, Q.
Format:	Artikel
Sprache:	fre
Schlagworte:	Animals Betacoronavirus - genetics Betacoronavirus - immunology Betacoronavirus - ultrastructure Coronavirus Infections - complications Coronavirus Infections - epidemiology Coronavirus Infections - immunology Coronavirus Infections - therapy COVID-19 Cytokines - metabolism General & Internal Medicine Humans Immunization Immunomodulation Life Sciences & Biomedicine Medicine, General & Internal Organ Specificity Pandemics Pneumonia, Viral - complications Pneumonia, Viral - epidemiology Pneumonia, Viral - immunology Pneumonia, Viral - therapy SARS-CoV-2 Science & Technology Thrombosis - prevention & control Thrombosis - virology Viral Tropism Virus Internalization Virus Replication - physiology Zoonoses - virology
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Zusammenfassung:	SARS-CoV-2 infection, named COVID-19, can lead to a dysregulated immune response and abnormal coagulation responsible for a viral sepsis. In this review, we specify physiopathological mechanisms of each phase of COVID-19 - viral, immune and pro-thrombotic - notably because they involve different treatment. Finally, we specify the physiopathological mechanisms of organ injury. (C) 2020 Societe Nationale Francaise de Medecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.
ISSN:	0248-8663 1768-3122
DOI:	10.1016/j.revmed.2020.05.003