Accurate automatic detection of acute lymphatic leukemia using a refined simple classification

An improved classification technique is presented to identify automatically the acute lymphatic leukemia (ALL) subtypes. An adaptive segmentation procedure is performed on peripheral blood smear images to extract the main features (10 geometric features) from the segmented images of white blood cell (WBC), nucleus, and cytoplasm. To show the importance of the different extracted features for the diagnostic accuracy, a comprehensive study is made on all the possible permutation cases of the features using powerful classifiers which are K‐nearest neighbor (KNN) at different metric functions, support vector machine (SVM) with different kernels, and artificial neural network (ANN). This procedure enables us to construct a feature map depending only on least number of features which lead to the highest diagnostic accuracy. It is found that the features map regarding the vacuoles in the cytoplasm and the regularity of the nucleus membrane gives the highest accurate results. The automatic classification for ALL subtypes based only on these two effective features is assessed using the receiver operating characteristic (ROC) curve and F1‐score measures. It is confirmed that the present technique is highly accurate, and saves the effort and time of training. A simple feature map is presented to improve an automatic identification system for acute lymphatic leukemia (ALL) subtypes. An adaptive segmentation procedure is performed on peripheral blood smear images to extract the main features. Powerful classifiers are used as K‐nearest neighbor (KNN) at different metric functions, support vector machine (SVM) with different kernels, and artificial neural network (ANN). A comprehensive study is made on all the possible permutation cases of these features to select the features with the highest diagnostic accuracy. A feature map depending only on the least significant features (two features) is presented. The classification for ALL subtypes is assessed using ROC curve and F1‐score measures.