Diverse effects of hepatic steatosis on fibrosis progression and functional cure in virologically quiescent chronic hepatitis B

Concomitant non-alcoholic fatty liver disease is common in patients with chronic hepatitis B (CHB) infection, although its impact on liver-related outcomes remains controversial. We aimed to study the effect of hepatic steatosis on the risk of fibrosis progression and the likelihood of HBsAg serocle...

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Veröffentlicht in:	Journal of hepatology 2020-10, Vol.73 (4), p.800-806
Hauptverfasser:	Mak, Lung-Yi, Hui, Rex Wan-Hin, Fung, James, Liu, Fen, Wong, Danny Ka-Ho, Cheung, Ka-Shing, Yuen, Man-Fung, Seto, Wai-Kay
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Alanine transaminase Chronic infection Deoxyribonucleic acid DNA Fatty liver Fibrosis Functional cure HBV Hepatitis B Hepatitis B surface antigen Interferon Liver diseases Liver stiffness Metabolic NAFLD Risk assessment Steatosis VCTE Viremia
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Beschreibung
Zusammenfassung:	Concomitant non-alcoholic fatty liver disease is common in patients with chronic hepatitis B (CHB) infection, although its impact on liver-related outcomes remains controversial. We aimed to study the effect of hepatic steatosis on the risk of fibrosis progression and the likelihood of HBsAg seroclearance. Treatment-naïve patients with CHB, normal alanine aminotransferase and low viraemia (serum HBV DNA
ISSN:	0168-8278 1600-0641
DOI:	10.1016/j.jhep.2020.05.040