Stress & executive functioning: A review considering moderating factors

[Display omitted] •Inconsistencies in the association between stress and cognition are outlined.•Analysis of neuroendocrine stress research and its relevance for cognition.•Moderators in the association between stress and cognition are analyzed.•Moderators include experimental and task-specific factors, and individual differences.•A systematic framework for the classification of studies on this topic is provided. A multitude of studies investigating the effects of stress on cognition has produced an inconsistent picture on whether - and under which conditions - stress has advantageous or disadvantageous effects on executive functions (EF). This review provides a short introduction to the concept of stress and its neurobiology, before discussing the need to consider moderating factors in the association between stress and EF. Three core domains are described and discussed in relation to the interplay between stress and cognition: the influence of different paradigms on physiological stress reactivity, individual differences in demographic and biological factors, and task-related features of cognitive tasks. Although some moderating variables such as the endocrine stress response have frequently been considered in single studies, no attempt of a holistic overview has been made so far. Therefore, we propose a more nuanced and systematic framework to study the effects of stress on executive functioning, comprising a holistic overview from the induction of stress, via biological mechanisms and interactions with individual differences, to the influence of stress on cognitive performance.