IgE-Mediated Hypersensitivity to Lysine Clonixinate

Villalon Garcia et al discuss the case study of a 70-year-old woman had been prescribed lysine clonixinate for headache. Thirty minutes following the first 250-mg intake, she developed itching in the ears, armpits, and arms and, progressively, generalized rash without angioedema. She did not develop dyspnea, stomach pain, or other systemic symptoms. She was treated in the emergency department with antihistamines and intramuscular corticosteroids, and her symptoms resolved completely in 2 hours. A month later, she reported a reaction similar to that following the first 250-mg intake. She subsequently tolerated paracetamol at 2 g/d. Skin prick test and single-blind, placebo-controlled oral challenge with lysine clonixinate, morniflumate, isonixin, niflumic acid, and acetylsalicylic acid were performed 2-3 months after the reaction and once written consent had been obtained.