Association of gene polymorphisms of CD55 with susceptibility to and severity of hand, foot, and mouth disease caused by enterovirus 71 in the Han Chinese population

Hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71) can lead to high morbidity and mortality, and genetic background plays an important role during the disease process. We investigated the association between the single‐nucleotide polymorphism (SNP) rs2564978 of the CD55 gene and su...

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Veröffentlicht in:	Journal of medical virology 2020-12, Vol.92 (12), p.3119-3124
Hauptverfasser:	Li, Mei, Li, Ya‐Ping, Deng, Hui‐Ling, Wang, Mu‐Qi, Wang, Wen‐Jun, Wang, Jun, Wu, Feng‐Ping, Dang, Shuang‐Suo
Format:	Artikel
Sprache:	eng
Schlagworte:	CD55 Antigens - genetics Child Child, Preschool China - epidemiology East Asian People - genetics Enterovirus A, Human - genetics Enteroviruses Female Gene polymorphism Genetic Predisposition to Disease Genotype Hand, Foot and Mouth Disease - genetics Hand, Foot and Mouth Disease - virology Hand-foot-and-mouth disease Health risks Humans Infant Infections Male Morbidity Nucleotides Polymorphism Polymorphism, Single Nucleotide Severity of Illness Index Single-nucleotide polymorphism Susceptibility Virology
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Zusammenfassung:	Hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71) can lead to high morbidity and mortality, and genetic background plays an important role during the disease process. We investigated the association between the single‐nucleotide polymorphism (SNP) rs2564978 of the CD55 gene and susceptibility to and severity of HFMD using the SNPs can multiple SNP typing methods. Soluble CD55 (sCD55) expression was significantly lower in the EV71 HFMD group than in the control group and lower in severe cases than in mild cases (P
ISSN:	0146-6615 1096-9071 1096-9071
DOI:	10.1002/jmv.26088