Prognostic effects of histology‐based tumour microenvironment scores in resected distal bile duct cancer
Aims Histology‐based tumour microenvironment (TME) scores are useful in predicting the prognosis of gastrointestinal cancer. However, their prognostic roles in distal bile duct cancer (DBDC) have not been previously studied. This study aimed to evaluate the prognostic significance of the TME scores...
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| Veröffentlicht in: | Histopathology 2020-09, Vol.77 (3), p.402-412 |
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| container_title | Histopathology |
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| creator | Hwang, Hye W Kim, Joo Y Lee, Seung E Choi, Yoo S Hong, Sook‐Hee Lee, Tae J. Kim, Mi K. Park, Eon S. Hong, Soon A. |
| description | Aims
Histology‐based tumour microenvironment (TME) scores are useful in predicting the prognosis of gastrointestinal cancer. However, their prognostic roles in distal bile duct cancer (DBDC) have not been previously studied. This study aimed to evaluate the prognostic significance of the TME scores using the Klintrup–Mäkinen (KM) grade, tumour stroma percentage (TSP) and the Glasgow microenvironment score (GMS) in resected DBDC.
Methods and results
Eighty‐one patients with DBDC who underwent curative resection were enrolled. DBDC was graded according to KM grade, TSP and GMS. A high KM grade was found in 19 patients (24%) and a high TSP was found in 47 patients (58%). A high TSP was significantly correlated with a low KM grade (P |
| doi_str_mv | 10.1111/his.14163 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2408198859</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2408198859</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3533-1061d6a7b29b05b453dc5db3fe07825e90a8ce07e9833599daa0c24c172df3643</originalsourceid><addsrcrecordid>eNp1kc1O3DAQx62qqCwfh75AZakXOGTXH3EcHytUWCQkkIBz5NgTmlUSb-2Eam88As_IkzCwwAGpvowPv_lp5j-EfOdszvEt_rRpznNeyC9kxmWhMqGU-UpmTDKTMV7oXbKX0ooxrqUQ38iuFLmWTIoZWV3FcDeENLaOQtOAGxMNDUXjGLpwt3l6eKxtAk_HqQ9TpH3rYoDhvo1h6GEYaXIhQqLtQLFgO6Iem21H67YD6ic3UmcHB_GA7DS2S3D4VvfJ7envm5NldnF5dn7y6yJzUkmZcVZwX1hdC1MzVedKeqd8LRtguhQKDLOlwz-YUkpljLeWOZE7roVvZJHLfXK09a5j-DtBGqu-TQ66zg4QplSJnJXclKUyiP78hK5wyQGnQyrnZa4LrZE63lK4ekoRmmod297GTcVZ9XKACuOqXg-A7I8341T34D_I98QRWGyBfxjP5v-manl-vVU-A_FBkQ4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2441847677</pqid></control><display><type>article</type><title>Prognostic effects of histology‐based tumour microenvironment scores in resected distal bile duct cancer</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Hwang, Hye W ; Kim, Joo Y ; Lee, Seung E ; Choi, Yoo S ; Hong, Sook‐Hee ; Lee, Tae J. ; Kim, Mi K. ; Park, Eon S. ; Hong, Soon A.</creator><creatorcontrib>Hwang, Hye W ; Kim, Joo Y ; Lee, Seung E ; Choi, Yoo S ; Hong, Sook‐Hee ; Lee, Tae J. ; Kim, Mi K. ; Park, Eon S. ; Hong, Soon A.</creatorcontrib><description>Aims
Histology‐based tumour microenvironment (TME) scores are useful in predicting the prognosis of gastrointestinal cancer. However, their prognostic roles in distal bile duct cancer (DBDC) have not been previously studied. This study aimed to evaluate the prognostic significance of the TME scores using the Klintrup–Mäkinen (KM) grade, tumour stroma percentage (TSP) and the Glasgow microenvironment score (GMS) in resected DBDC.
Methods and results
Eighty‐one patients with DBDC who underwent curative resection were enrolled. DBDC was graded according to KM grade, TSP and GMS. A high KM grade was found in 19 patients (24%) and a high TSP was found in 47 patients (58%). A high TSP was significantly correlated with a low KM grade (P < 0.001). The distribution of the GMS, which was developed by combining the KM grade and TSP, was as follows: 0 (n = 19, 24%), 1 (n = 19, 24%) and 2 (n = 43, 52%). A low KM grade, high TSP and high GMS were significantly associated with short overall survival (OS) (P < 0.001) and relapse‐free survival (RFS) (P < 0.001). Furthermore, multivariate analysis showed that a low KM grade [hazard ratio (HR) = 3.826; confidence interval (CI) = 1.650–8.869; P = 0.014], high TSP (HR = 2.193; CI = 1.173–4.100, P = 0.002) and high GMS (HR = 7.148; CI = 2.811–18.173) were independent prognostic factors for short RFS; a low KM grade (HR = 4.324; CI = 1.594–11.733) and high GMS (HR = 6.332; CI = 2.743–14.594) were independent prognostic factors for short OS.
Conclusion
Histology‐based TME scores, including the KM grade, TSP and GMS, are useful for predicting the survival of patients with resected DBDC.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/his.14163</identifier><identifier>PMID: 32473032</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Bile ; Bile ducts ; Cancer ; distal bile duct cancer ; Histology ; Medical prognosis ; Multivariate analysis ; Stroma ; Survival ; Tumor microenvironment ; Tumors ; tumour microenvironment</subject><ispartof>Histopathology, 2020-09, Vol.77 (3), p.402-412</ispartof><rights>2020 John Wiley & Sons Ltd</rights><rights>This article is protected by copyright. All rights reserved.</rights><rights>Copyright © 2020 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-1061d6a7b29b05b453dc5db3fe07825e90a8ce07e9833599daa0c24c172df3643</citedby><cites>FETCH-LOGICAL-c3533-1061d6a7b29b05b453dc5db3fe07825e90a8ce07e9833599daa0c24c172df3643</cites><orcidid>0000-0002-7902-4608</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhis.14163$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhis.14163$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32473032$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwang, Hye W</creatorcontrib><creatorcontrib>Kim, Joo Y</creatorcontrib><creatorcontrib>Lee, Seung E</creatorcontrib><creatorcontrib>Choi, Yoo S</creatorcontrib><creatorcontrib>Hong, Sook‐Hee</creatorcontrib><creatorcontrib>Lee, Tae J.</creatorcontrib><creatorcontrib>Kim, Mi K.</creatorcontrib><creatorcontrib>Park, Eon S.</creatorcontrib><creatorcontrib>Hong, Soon A.</creatorcontrib><title>Prognostic effects of histology‐based tumour microenvironment scores in resected distal bile duct cancer</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims
Histology‐based tumour microenvironment (TME) scores are useful in predicting the prognosis of gastrointestinal cancer. However, their prognostic roles in distal bile duct cancer (DBDC) have not been previously studied. This study aimed to evaluate the prognostic significance of the TME scores using the Klintrup–Mäkinen (KM) grade, tumour stroma percentage (TSP) and the Glasgow microenvironment score (GMS) in resected DBDC.
Methods and results
Eighty‐one patients with DBDC who underwent curative resection were enrolled. DBDC was graded according to KM grade, TSP and GMS. A high KM grade was found in 19 patients (24%) and a high TSP was found in 47 patients (58%). A high TSP was significantly correlated with a low KM grade (P < 0.001). The distribution of the GMS, which was developed by combining the KM grade and TSP, was as follows: 0 (n = 19, 24%), 1 (n = 19, 24%) and 2 (n = 43, 52%). A low KM grade, high TSP and high GMS were significantly associated with short overall survival (OS) (P < 0.001) and relapse‐free survival (RFS) (P < 0.001). Furthermore, multivariate analysis showed that a low KM grade [hazard ratio (HR) = 3.826; confidence interval (CI) = 1.650–8.869; P = 0.014], high TSP (HR = 2.193; CI = 1.173–4.100, P = 0.002) and high GMS (HR = 7.148; CI = 2.811–18.173) were independent prognostic factors for short RFS; a low KM grade (HR = 4.324; CI = 1.594–11.733) and high GMS (HR = 6.332; CI = 2.743–14.594) were independent prognostic factors for short OS.
Conclusion
Histology‐based TME scores, including the KM grade, TSP and GMS, are useful for predicting the survival of patients with resected DBDC.</description><subject>Bile</subject><subject>Bile ducts</subject><subject>Cancer</subject><subject>distal bile duct cancer</subject><subject>Histology</subject><subject>Medical prognosis</subject><subject>Multivariate analysis</subject><subject>Stroma</subject><subject>Survival</subject><subject>Tumor microenvironment</subject><subject>Tumors</subject><subject>tumour microenvironment</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kc1O3DAQx62qqCwfh75AZakXOGTXH3EcHytUWCQkkIBz5NgTmlUSb-2Eam88As_IkzCwwAGpvowPv_lp5j-EfOdszvEt_rRpznNeyC9kxmWhMqGU-UpmTDKTMV7oXbKX0ooxrqUQ38iuFLmWTIoZWV3FcDeENLaOQtOAGxMNDUXjGLpwt3l6eKxtAk_HqQ9TpH3rYoDhvo1h6GEYaXIhQqLtQLFgO6Iem21H67YD6ic3UmcHB_GA7DS2S3D4VvfJ7envm5NldnF5dn7y6yJzUkmZcVZwX1hdC1MzVedKeqd8LRtguhQKDLOlwz-YUkpljLeWOZE7roVvZJHLfXK09a5j-DtBGqu-TQ66zg4QplSJnJXclKUyiP78hK5wyQGnQyrnZa4LrZE63lK4ekoRmmod297GTcVZ9XKACuOqXg-A7I8341T34D_I98QRWGyBfxjP5v-manl-vVU-A_FBkQ4</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Hwang, Hye W</creator><creator>Kim, Joo Y</creator><creator>Lee, Seung E</creator><creator>Choi, Yoo S</creator><creator>Hong, Sook‐Hee</creator><creator>Lee, Tae J.</creator><creator>Kim, Mi K.</creator><creator>Park, Eon S.</creator><creator>Hong, Soon A.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7902-4608</orcidid></search><sort><creationdate>202009</creationdate><title>Prognostic effects of histology‐based tumour microenvironment scores in resected distal bile duct cancer</title><author>Hwang, Hye W ; Kim, Joo Y ; Lee, Seung E ; Choi, Yoo S ; Hong, Sook‐Hee ; Lee, Tae J. ; Kim, Mi K. ; Park, Eon S. ; Hong, Soon A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3533-1061d6a7b29b05b453dc5db3fe07825e90a8ce07e9833599daa0c24c172df3643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Bile</topic><topic>Bile ducts</topic><topic>Cancer</topic><topic>distal bile duct cancer</topic><topic>Histology</topic><topic>Medical prognosis</topic><topic>Multivariate analysis</topic><topic>Stroma</topic><topic>Survival</topic><topic>Tumor microenvironment</topic><topic>Tumors</topic><topic>tumour microenvironment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hwang, Hye W</creatorcontrib><creatorcontrib>Kim, Joo Y</creatorcontrib><creatorcontrib>Lee, Seung E</creatorcontrib><creatorcontrib>Choi, Yoo S</creatorcontrib><creatorcontrib>Hong, Sook‐Hee</creatorcontrib><creatorcontrib>Lee, Tae J.</creatorcontrib><creatorcontrib>Kim, Mi K.</creatorcontrib><creatorcontrib>Park, Eon S.</creatorcontrib><creatorcontrib>Hong, Soon A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, Hye W</au><au>Kim, Joo Y</au><au>Lee, Seung E</au><au>Choi, Yoo S</au><au>Hong, Sook‐Hee</au><au>Lee, Tae J.</au><au>Kim, Mi K.</au><au>Park, Eon S.</au><au>Hong, Soon A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic effects of histology‐based tumour microenvironment scores in resected distal bile duct cancer</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2020-09</date><risdate>2020</risdate><volume>77</volume><issue>3</issue><spage>402</spage><epage>412</epage><pages>402-412</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Aims
Histology‐based tumour microenvironment (TME) scores are useful in predicting the prognosis of gastrointestinal cancer. However, their prognostic roles in distal bile duct cancer (DBDC) have not been previously studied. This study aimed to evaluate the prognostic significance of the TME scores using the Klintrup–Mäkinen (KM) grade, tumour stroma percentage (TSP) and the Glasgow microenvironment score (GMS) in resected DBDC.
Methods and results
Eighty‐one patients with DBDC who underwent curative resection were enrolled. DBDC was graded according to KM grade, TSP and GMS. A high KM grade was found in 19 patients (24%) and a high TSP was found in 47 patients (58%). A high TSP was significantly correlated with a low KM grade (P < 0.001). The distribution of the GMS, which was developed by combining the KM grade and TSP, was as follows: 0 (n = 19, 24%), 1 (n = 19, 24%) and 2 (n = 43, 52%). A low KM grade, high TSP and high GMS were significantly associated with short overall survival (OS) (P < 0.001) and relapse‐free survival (RFS) (P < 0.001). Furthermore, multivariate analysis showed that a low KM grade [hazard ratio (HR) = 3.826; confidence interval (CI) = 1.650–8.869; P = 0.014], high TSP (HR = 2.193; CI = 1.173–4.100, P = 0.002) and high GMS (HR = 7.148; CI = 2.811–18.173) were independent prognostic factors for short RFS; a low KM grade (HR = 4.324; CI = 1.594–11.733) and high GMS (HR = 6.332; CI = 2.743–14.594) were independent prognostic factors for short OS.
Conclusion
Histology‐based TME scores, including the KM grade, TSP and GMS, are useful for predicting the survival of patients with resected DBDC.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32473032</pmid><doi>10.1111/his.14163</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-7902-4608</orcidid></addata></record> |
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| subjects | Bile Bile ducts Cancer distal bile duct cancer Histology Medical prognosis Multivariate analysis Stroma Survival Tumor microenvironment Tumors tumour microenvironment |
| title | Prognostic effects of histology‐based tumour microenvironment scores in resected distal bile duct cancer |
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