Prognostic effects of histology‐based tumour microenvironment scores in resected distal bile duct cancer

Prognostic effects of histology‐based tumour microenvironment scores in resected distal bile duct cancer

Aims Histology‐based tumour microenvironment (TME) scores are useful in predicting the prognosis of gastrointestinal cancer. However, their prognostic roles in distal bile duct cancer (DBDC) have not been previously studied. This study aimed to evaluate the prognostic significance of the TME scores...

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Veröffentlicht in:Histopathology 2020-09, Vol.77 (3), p.402-412
Hauptverfasser: Hwang, Hye W, Kim, Joo Y, Lee, Seung E, Choi, Yoo S, Hong, Sook‐Hee, Lee, Tae J., Kim, Mi K., Park, Eon S., Hong, Soon A.
Format: Artikel
Sprache:eng
Schlagworte:
Bile
Bile ducts
Cancer
distal bile duct cancer
Histology
Medical prognosis
Multivariate analysis
Stroma
Survival
Tumor microenvironment
Tumors
tumour microenvironment
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Zusammenfassung:Aims Histology‐based tumour microenvironment (TME) scores are useful in predicting the prognosis of gastrointestinal cancer. However, their prognostic roles in distal bile duct cancer (DBDC) have not been previously studied. This study aimed to evaluate the prognostic significance of the TME scores using the Klintrup–Mäkinen (KM) grade, tumour stroma percentage (TSP) and the Glasgow microenvironment score (GMS) in resected DBDC. Methods and results Eighty‐one patients with DBDC who underwent curative resection were enrolled. DBDC was graded according to KM grade, TSP and GMS. A high KM grade was found in 19 patients (24%) and a high TSP was found in 47 patients (58%). A high TSP was significantly correlated with a low KM grade (P 
ISSN:0309-0167
1365-2559
DOI:10.1111/his.14163