Vortioxetine reduces pain hypersensitivity and associated depression-like behavior in mice with oxaliplatin-induced neuropathy

Chronic pain and depression commonly occur together so dual-acting agents might be particularly useful. The population of patients with chemotherapy-induced neuropathy is increasing in parallel with the increase of population of cancer survivors and there is a compelling need for satisfactory treatm...

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Veröffentlicht in:Progress in neuro-psychopharmacology & biological psychiatry 2020-12, Vol.103, p.109975-109975, Article 109975
Hauptverfasser: Micov, Ana M., Tomić, Maja A., Todorović, Marija B., Vuković, Milja J., Pecikoza, Uroš B., Jasnic, Nebojsa I., Djordjevic, Jelena D., Stepanović-Petrović, Radica M.
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Sprache:eng
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Zusammenfassung:Chronic pain and depression commonly occur together so dual-acting agents might be particularly useful. The population of patients with chemotherapy-induced neuropathy is increasing in parallel with the increase of population of cancer survivors and there is a compelling need for satisfactory treatment of symptoms of neuropathy and concomitant depression. We examined the effects of vortioxetine, a novel antidepressant with unique mechanism of action, on pain hypersensitivity and depression-like behavior in oxaliplatin-induced neuropathy model in mice (OIPN). Vortioxetine (1–10 mg/kg, p.o.) significantly and dose-dependently reduced mechanical allodynia in von Frey test and cold allodynia in acetone test in OIPN mice, in both repeated prophylactic and acute therapeutic treatment regimens. It also reduced depression-like behavior in the forced swimming test in OIPN mice, in both treatment paradigms. Its antiallodynic and antidepressive-like effects were comparable to those exerted by duloxetine (1–15 mg/kg, p.o.). The antiallodynic and antidepressive-like effects of repeatedly administered vortioxetine might be related to the increased content of 5-hydroxytryptamine (5-HT) and noradrenaline (NA), detected in the brainstem of treated OIPN mice. These results indicate that vortioxetine could be potentially useful in prevention and treatment of chemotherapy-induced neuropathy, for the relief of pain and concomitant depressive symptoms. It should be further tested to this regard in clinical settings. •Vortioxetine exerted antiallodynic effects in chemotherapy-induced neuropathy model.•It also reduced pain-related depression-like behavior.•Effects were produced in repeated prophylactic and acute therapeutic dose regimens.•Effects were dose-dependent and comparable with the effects of duloxetine.•Effects might be related to increased serotonin and noradrenaline in the brainstem.
ISSN:0278-5846
1878-4216
DOI:10.1016/j.pnpbp.2020.109975