Grey-Matter Thickness of the Left But Not the Right Primary Visual Area Correlates with Autism Traits in Typically Developing Adults

We examined whether functional and structural variability in the primary visual area (V1) correlated with autism traits. Twenty-nine participants (16 males; M Age = 26.4 years, SD Age = 4.0 years) completed the autism-spectrum quotient (AQ) questionnaire prior to a magnetic resonance imaging sessi...

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Veröffentlicht in:	Journal of autism and developmental disorders 2021-02, Vol.51 (2), p.405-417
Hauptverfasser:	Yildiz, Gizem Y., Vilsten, Julian S., Millard, Amy Siobhan, Chouinard, Philippe A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Autism Autistic Disorder - diagnostic imaging Autistic Disorder - psychology Behavioral Science and Psychology Brain Hemisphere Functions Child and School Psychology Correlation Development and progression Female Functional Laterality - physiology Gray Matter - diagnostic imaging Gray Matter - physiology Humans Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Males Medical examination Men Nerve tissue Neurosciences Organ Size - physiology Original Paper Pediatrics Pervasive Developmental Disorders Photic Stimulation - methods Physiological aspects Psychology Public Health Risk factors Self Report Stimulation Structure-function relationships Surveys and Questionnaires Symptoms (Individual Disorders) Visual cortex Visual Cortex - diagnostic imaging Visual Cortex - physiology Visual Stimuli Young Adult Young Adults
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Zusammenfassung:	We examined whether functional and structural variability in the primary visual area (V1) correlated with autism traits. Twenty-nine participants (16 males; M Age = 26.4 years, SD Age = 4.0 years) completed the autism-spectrum quotient (AQ) questionnaire prior to a magnetic resonance imaging session. The total AQ scores was used to assess the degree of self-reported autism traits. The average functional activation in V1 to visual stimulation and its average grey-matter thickness were calculated. There were no correlations between functional activation in V1 and autism traits. Conversely, grey-matter thickness of the left but not the right V1 correlated with autism traits. We conclude that structural changes in the left V1 could be a marker for the presence of autism traits.
ISSN:	0162-3257 1573-3432
DOI:	10.1007/s10803-020-04553-w