The usefulness of the retinal sensitivity measurement with a microperimetry for predicting the visual prognosis of branch retinal vein occlusion with macular edema
Purpose To evaluate the usefulness of the retinal sensitivity in branch retinal vein occlusion (BVO) with macular edema (ME) following the anti-vascular endothelial growth factor (anti-VEGF) treatment. Methods Best-corrected visual acuity (BCVA), microperimetry, and optical coherence tomography (OCT...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 2020-09, Vol.258 (9), p.1949-1958 |
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| container_issue | 9 |
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| container_title | Graefe's archive for clinical and experimental ophthalmology |
| container_volume | 258 |
| creator | Fujino, Ryosuke Asaoka, Ryo Aoki, Shuichiro Sugiura, Aya Kusakabe, Mari Asano-Shimizu, Kimiko Nomura, Yoko Aoki, Aya Hashimoto, Yohei Azuma, Keiko Inoue, Tatsuya Obata, Ryo |
| description | Purpose
To evaluate the usefulness of the retinal sensitivity in branch retinal vein occlusion (BVO) with macular edema (ME) following the anti-vascular endothelial growth factor (anti-VEGF) treatment.
Methods
Best-corrected visual acuity (BCVA), microperimetry, and optical coherence tomography (OCT) measurements were carried out in 20 patients with BVO with ME, at baseline and 1 month after the anti-VEGF treatment. The relationships among BCVA, mean retinal sensitivity (MS), macular volume (MV), central retinal thickness (CRT), integrity of ellipsoid zone (EZ), mean retinal sensitivity in the most affected quadrant (qMS), and macular volume in the most affected quadrant (qMV) were investigated. In addition, the relationships among the change in BCVA at 1 month (ΔBCVA1m), mean sensitivity in the most affected quadrant at 1 month (ΔqMS1m), MV in the most affected quadrant at 1 month (ΔqMV1m), and CRT at 1 month (ΔCRT1m) were analyzed. The optimal model for BCVA at 3 months after the treatment (BCVA3m) was identified.
Results
There was not a significant difference in BCVA (paired Wilcoxon test,
p
= 0.058) between at baseline and after the treatment, but there were significant differences in MS, MV, CRT, qMS, and qMV (
p
|
| doi_str_mv | 10.1007/s00417-020-04759-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2407313676</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2435337497</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-a94b6de5d4dd02bf250ae73213a257a461c3a53f90f47735ea0ec2e59565a62a3</originalsourceid><addsrcrecordid>eNqNksuKFDEYhQtRnHb0BVxIwI0wlOZa6doIQ-OoMOBmhNmFVOqv7gxVSZtLD_08vqjprrG9LMRVQvKdk5zkVNVLgt8SjOW7iDEnssYU15hL0dbto2pBOBO1xPT2cbXAkpJ6yejtWfUsxjtceCbI0-qMUS6WxWNRfb_ZAMoRhjw6iBH5AaWyEiBZp0cUwUWb7M6mPZpAxxxgApfQvU0bpNFkTfBbCHaCFPZo8AFtA_TWFPX6aLSzMRefbfBr56M9HtAF7czmdMYOrEPemDFH691sPWmTRx0Q9DDp59WTQY8RXjyM59XXqw83q0_19ZePn1eX17Xhkqdat7xrehA973tMu4EKrEEySpimQmreEMO0YEOLBy4lE6AxGAqiFY3QDdXsvHo_-25zN0FvStCgR7Ut8XTYK6-t-nPH2Y1a-52SnC3ZkhSDNw8GwX_LEJOabDQwjtqBz1FRjiUjrJFNQV__hd75HMpzHCgmGJO8lYWiM1WeOcYAw-kyBKtDB9TcAVU6oI4dUG0Rvfo9xkny89MLcDED99D5IRoLzsAJKy0RgommZWWGD6GW_0-vbNKp_OLKZ5eKlM3SWHC3hvAr5D_u_wPmbOK_</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2435337497</pqid></control><display><type>article</type><title>The usefulness of the retinal sensitivity measurement with a microperimetry for predicting the visual prognosis of branch retinal vein occlusion with macular edema</title><source>SpringerNature Journals</source><creator>Fujino, Ryosuke ; Asaoka, Ryo ; Aoki, Shuichiro ; Sugiura, Aya ; Kusakabe, Mari ; Asano-Shimizu, Kimiko ; Nomura, Yoko ; Aoki, Aya ; Hashimoto, Yohei ; Azuma, Keiko ; Inoue, Tatsuya ; Obata, Ryo</creator><creatorcontrib>Fujino, Ryosuke ; Asaoka, Ryo ; Aoki, Shuichiro ; Sugiura, Aya ; Kusakabe, Mari ; Asano-Shimizu, Kimiko ; Nomura, Yoko ; Aoki, Aya ; Hashimoto, Yohei ; Azuma, Keiko ; Inoue, Tatsuya ; Obata, Ryo</creatorcontrib><description>Purpose
To evaluate the usefulness of the retinal sensitivity in branch retinal vein occlusion (BVO) with macular edema (ME) following the anti-vascular endothelial growth factor (anti-VEGF) treatment.
Methods
Best-corrected visual acuity (BCVA), microperimetry, and optical coherence tomography (OCT) measurements were carried out in 20 patients with BVO with ME, at baseline and 1 month after the anti-VEGF treatment. The relationships among BCVA, mean retinal sensitivity (MS), macular volume (MV), central retinal thickness (CRT), integrity of ellipsoid zone (EZ), mean retinal sensitivity in the most affected quadrant (qMS), and macular volume in the most affected quadrant (qMV) were investigated. In addition, the relationships among the change in BCVA at 1 month (ΔBCVA1m), mean sensitivity in the most affected quadrant at 1 month (ΔqMS1m), MV in the most affected quadrant at 1 month (ΔqMV1m), and CRT at 1 month (ΔCRT1m) were analyzed. The optimal model for BCVA at 3 months after the treatment (BCVA3m) was identified.
Results
There was not a significant difference in BCVA (paired Wilcoxon test,
p
= 0.058) between at baseline and after the treatment, but there were significant differences in MS, MV, CRT, qMS, and qMV (
p
< 0.05). There was a significant relationship between ΔqMS1m and ΔMV1m, ΔCRT1m, and ΔqMV1m, respectively. ΔMS1m or ΔqMS1m and BCVA at baseline and ΔBCVA1m were selected as explanatory variables in the optimal model for BCVA3m.
Conclusion
Retinal sensitivity was related to retinal structure, whereas this was not the case with BCVA. In addition, retinal sensitivity was useful to predict BCVA after anti-VEGF therapy.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-020-04759-9</identifier><identifier>PMID: 32458100</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acuity ; Edema ; Life Sciences & Biomedicine ; Medicine ; Medicine & Public Health ; Occlusion ; Ophthalmology ; Retina ; Retinal Disorders ; Science & Technology ; Vascular endothelial growth factor</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2020-09, Vol.258 (9), p.1949-1958</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>11</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000553569300001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c474t-a94b6de5d4dd02bf250ae73213a257a461c3a53f90f47735ea0ec2e59565a62a3</citedby><cites>FETCH-LOGICAL-c474t-a94b6de5d4dd02bf250ae73213a257a461c3a53f90f47735ea0ec2e59565a62a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00417-020-04759-9$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00417-020-04759-9$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32458100$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujino, Ryosuke</creatorcontrib><creatorcontrib>Asaoka, Ryo</creatorcontrib><creatorcontrib>Aoki, Shuichiro</creatorcontrib><creatorcontrib>Sugiura, Aya</creatorcontrib><creatorcontrib>Kusakabe, Mari</creatorcontrib><creatorcontrib>Asano-Shimizu, Kimiko</creatorcontrib><creatorcontrib>Nomura, Yoko</creatorcontrib><creatorcontrib>Aoki, Aya</creatorcontrib><creatorcontrib>Hashimoto, Yohei</creatorcontrib><creatorcontrib>Azuma, Keiko</creatorcontrib><creatorcontrib>Inoue, Tatsuya</creatorcontrib><creatorcontrib>Obata, Ryo</creatorcontrib><title>The usefulness of the retinal sensitivity measurement with a microperimetry for predicting the visual prognosis of branch retinal vein occlusion with macular edema</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>GRAEF ARCH CLIN EXP</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
To evaluate the usefulness of the retinal sensitivity in branch retinal vein occlusion (BVO) with macular edema (ME) following the anti-vascular endothelial growth factor (anti-VEGF) treatment.
Methods
Best-corrected visual acuity (BCVA), microperimetry, and optical coherence tomography (OCT) measurements were carried out in 20 patients with BVO with ME, at baseline and 1 month after the anti-VEGF treatment. The relationships among BCVA, mean retinal sensitivity (MS), macular volume (MV), central retinal thickness (CRT), integrity of ellipsoid zone (EZ), mean retinal sensitivity in the most affected quadrant (qMS), and macular volume in the most affected quadrant (qMV) were investigated. In addition, the relationships among the change in BCVA at 1 month (ΔBCVA1m), mean sensitivity in the most affected quadrant at 1 month (ΔqMS1m), MV in the most affected quadrant at 1 month (ΔqMV1m), and CRT at 1 month (ΔCRT1m) were analyzed. The optimal model for BCVA at 3 months after the treatment (BCVA3m) was identified.
Results
There was not a significant difference in BCVA (paired Wilcoxon test,
p
= 0.058) between at baseline and after the treatment, but there were significant differences in MS, MV, CRT, qMS, and qMV (
p
< 0.05). There was a significant relationship between ΔqMS1m and ΔMV1m, ΔCRT1m, and ΔqMV1m, respectively. ΔMS1m or ΔqMS1m and BCVA at baseline and ΔBCVA1m were selected as explanatory variables in the optimal model for BCVA3m.
Conclusion
Retinal sensitivity was related to retinal structure, whereas this was not the case with BCVA. In addition, retinal sensitivity was useful to predict BCVA after anti-VEGF therapy.</description><subject>Acuity</subject><subject>Edema</subject><subject>Life Sciences & Biomedicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Occlusion</subject><subject>Ophthalmology</subject><subject>Retina</subject><subject>Retinal Disorders</subject><subject>Science & Technology</subject><subject>Vascular endothelial growth factor</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>AOWDO</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNksuKFDEYhQtRnHb0BVxIwI0wlOZa6doIQ-OoMOBmhNmFVOqv7gxVSZtLD_08vqjprrG9LMRVQvKdk5zkVNVLgt8SjOW7iDEnssYU15hL0dbto2pBOBO1xPT2cbXAkpJ6yejtWfUsxjtceCbI0-qMUS6WxWNRfb_ZAMoRhjw6iBH5AaWyEiBZp0cUwUWb7M6mPZpAxxxgApfQvU0bpNFkTfBbCHaCFPZo8AFtA_TWFPX6aLSzMRefbfBr56M9HtAF7czmdMYOrEPemDFH691sPWmTRx0Q9DDp59WTQY8RXjyM59XXqw83q0_19ZePn1eX17Xhkqdat7xrehA973tMu4EKrEEySpimQmreEMO0YEOLBy4lE6AxGAqiFY3QDdXsvHo_-25zN0FvStCgR7Ut8XTYK6-t-nPH2Y1a-52SnC3ZkhSDNw8GwX_LEJOabDQwjtqBz1FRjiUjrJFNQV__hd75HMpzHCgmGJO8lYWiM1WeOcYAw-kyBKtDB9TcAVU6oI4dUG0Rvfo9xkny89MLcDED99D5IRoLzsAJKy0RgommZWWGD6GW_0-vbNKp_OLKZ5eKlM3SWHC3hvAr5D_u_wPmbOK_</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Fujino, Ryosuke</creator><creator>Asaoka, Ryo</creator><creator>Aoki, Shuichiro</creator><creator>Sugiura, Aya</creator><creator>Kusakabe, Mari</creator><creator>Asano-Shimizu, Kimiko</creator><creator>Nomura, Yoko</creator><creator>Aoki, Aya</creator><creator>Hashimoto, Yohei</creator><creator>Azuma, Keiko</creator><creator>Inoue, Tatsuya</creator><creator>Obata, Ryo</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200901</creationdate><title>The usefulness of the retinal sensitivity measurement with a microperimetry for predicting the visual prognosis of branch retinal vein occlusion with macular edema</title><author>Fujino, Ryosuke ; Asaoka, Ryo ; Aoki, Shuichiro ; Sugiura, Aya ; Kusakabe, Mari ; Asano-Shimizu, Kimiko ; Nomura, Yoko ; Aoki, Aya ; Hashimoto, Yohei ; Azuma, Keiko ; Inoue, Tatsuya ; Obata, Ryo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-a94b6de5d4dd02bf250ae73213a257a461c3a53f90f47735ea0ec2e59565a62a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acuity</topic><topic>Edema</topic><topic>Life Sciences & Biomedicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Occlusion</topic><topic>Ophthalmology</topic><topic>Retina</topic><topic>Retinal Disorders</topic><topic>Science & Technology</topic><topic>Vascular endothelial growth factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujino, Ryosuke</creatorcontrib><creatorcontrib>Asaoka, Ryo</creatorcontrib><creatorcontrib>Aoki, Shuichiro</creatorcontrib><creatorcontrib>Sugiura, Aya</creatorcontrib><creatorcontrib>Kusakabe, Mari</creatorcontrib><creatorcontrib>Asano-Shimizu, Kimiko</creatorcontrib><creatorcontrib>Nomura, Yoko</creatorcontrib><creatorcontrib>Aoki, Aya</creatorcontrib><creatorcontrib>Hashimoto, Yohei</creatorcontrib><creatorcontrib>Azuma, Keiko</creatorcontrib><creatorcontrib>Inoue, Tatsuya</creatorcontrib><creatorcontrib>Obata, Ryo</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujino, Ryosuke</au><au>Asaoka, Ryo</au><au>Aoki, Shuichiro</au><au>Sugiura, Aya</au><au>Kusakabe, Mari</au><au>Asano-Shimizu, Kimiko</au><au>Nomura, Yoko</au><au>Aoki, Aya</au><au>Hashimoto, Yohei</au><au>Azuma, Keiko</au><au>Inoue, Tatsuya</au><au>Obata, Ryo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The usefulness of the retinal sensitivity measurement with a microperimetry for predicting the visual prognosis of branch retinal vein occlusion with macular edema</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><stitle>GRAEF ARCH CLIN EXP</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2020-09-01</date><risdate>2020</risdate><volume>258</volume><issue>9</issue><spage>1949</spage><epage>1958</epage><pages>1949-1958</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
To evaluate the usefulness of the retinal sensitivity in branch retinal vein occlusion (BVO) with macular edema (ME) following the anti-vascular endothelial growth factor (anti-VEGF) treatment.
Methods
Best-corrected visual acuity (BCVA), microperimetry, and optical coherence tomography (OCT) measurements were carried out in 20 patients with BVO with ME, at baseline and 1 month after the anti-VEGF treatment. The relationships among BCVA, mean retinal sensitivity (MS), macular volume (MV), central retinal thickness (CRT), integrity of ellipsoid zone (EZ), mean retinal sensitivity in the most affected quadrant (qMS), and macular volume in the most affected quadrant (qMV) were investigated. In addition, the relationships among the change in BCVA at 1 month (ΔBCVA1m), mean sensitivity in the most affected quadrant at 1 month (ΔqMS1m), MV in the most affected quadrant at 1 month (ΔqMV1m), and CRT at 1 month (ΔCRT1m) were analyzed. The optimal model for BCVA at 3 months after the treatment (BCVA3m) was identified.
Results
There was not a significant difference in BCVA (paired Wilcoxon test,
p
= 0.058) between at baseline and after the treatment, but there were significant differences in MS, MV, CRT, qMS, and qMV (
p
< 0.05). There was a significant relationship between ΔqMS1m and ΔMV1m, ΔCRT1m, and ΔqMV1m, respectively. ΔMS1m or ΔqMS1m and BCVA at baseline and ΔBCVA1m were selected as explanatory variables in the optimal model for BCVA3m.
Conclusion
Retinal sensitivity was related to retinal structure, whereas this was not the case with BCVA. In addition, retinal sensitivity was useful to predict BCVA after anti-VEGF therapy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32458100</pmid><doi>10.1007/s00417-020-04759-9</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2020-09, Vol.258 (9), p.1949-1958 |
| issn | 0721-832X 1435-702X |
| language | eng |
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| source | SpringerNature Journals |
| subjects | Acuity Edema Life Sciences & Biomedicine Medicine Medicine & Public Health Occlusion Ophthalmology Retina Retinal Disorders Science & Technology Vascular endothelial growth factor |
| title | The usefulness of the retinal sensitivity measurement with a microperimetry for predicting the visual prognosis of branch retinal vein occlusion with macular edema |
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