Bioactive platycodins from Platycodonis Radix: Phytochemistry, pharmacological activities, toxicology and pharmacokinetics
•Platycodins represent the main bioactive components of Platycodonis Radix.•More than 70 platycodins have been identified from Platycodonis Radix.•The platycodins possess various pharmacological activities.•Toxicology and pharmacokinetics of the platycodins have been summarized. Platycodonis Radix,...
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Veröffentlicht in: | Food chemistry 2020-10, Vol.327, p.127029-127029, Article 127029 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | •Platycodins represent the main bioactive components of Platycodonis Radix.•More than 70 platycodins have been identified from Platycodonis Radix.•The platycodins possess various pharmacological activities.•Toxicology and pharmacokinetics of the platycodins have been summarized.
Platycodonis Radix, the root of Platycodon grandiflorum (Jacq.) A. DC., is a well-known edible herbal medicine. It is a common vegetable used for the preparation of side dish, kimchi, dessert, and tea. Besides, it has been used to treat respiratory disease including cough, excessive phlegm, and sore throat for a long history. In the past decades, the bioactive components and the pharmacological activities of Platycodonis Radix have been widely investigated. Thereinto, platycodins, the oleanane-type triterpenoid saponins were demonstrated to be the main bioactive components in Platycodonis Radix, and more than 70 platycodins have been identified up to date. This paper mainly reviewed the phytochemistry, pharmacological activities (apophlegmatic, anti-tussive, anti-inflammatory, anti-cancer, anti-obesity, anti-diabetic, immunomodulatory, cardiovascular protective, and hepatoprotective activities, etc.), toxicology and pharmacokinetics of platycodins isolated from Platycodonis Radix, aiming to promote further investigation on therapeutic potential of these platycodins. |
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ISSN: | 0308-8146 1873-7072 |
DOI: | 10.1016/j.foodchem.2020.127029 |