The role of advanced glycation end products in human infertility
Advanced glycation end products (AGEs) are heterogeneous products of the non-enzymatic interaction between proteins and reducing sugars. Numerous studies have shown that AGEs are associated with senescence, diabetes, vascular disease, aging and kidney disease. Infertility has been affected approxima...
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| Veröffentlicht in: | Life sciences (1973) 2020-08, Vol.255, p.117830-117830, Article 117830 |
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| container_end_page | 117830 |
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| container_title | Life sciences (1973) |
| container_volume | 255 |
| creator | Zhu, Jing-ling Cai, Ya-qin Long, Shuang-lian Chen, Zhuo Mo, Zhong-cheng |
| description | Advanced glycation end products (AGEs) are heterogeneous products of the non-enzymatic interaction between proteins and reducing sugars. Numerous studies have shown that AGEs are associated with senescence, diabetes, vascular disease, aging and kidney disease. Infertility has been affected approximately 10 to15% of couples of reproductive ages. AGEs accumulation has been shown to play a crucial role in pathogenesis of infertility-related diseases. The present review provides the generation process, mechanism and pathological significance of AGEs and the novel treatment targeting AGEs for infertility.
[Display omitted]
•Increased exogenous AGEs intake and hyperglycemia and hyperlipidemia increased serum AGEs levels.•Elevated serum AGEs levels increase the risk of infertility.•AGEs damage male and female reproductive tract by increasing oxidative stress.•Treatments targeting AGE-RAGE system will provide a fresh idea for improving infertility. |
| doi_str_mv | 10.1016/j.lfs.2020.117830 |
| format | Article |
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[Display omitted]
•Increased exogenous AGEs intake and hyperglycemia and hyperlipidemia increased serum AGEs levels.•Elevated serum AGEs levels increase the risk of infertility.•AGEs damage male and female reproductive tract by increasing oxidative stress.•Treatments targeting AGE-RAGE system will provide a fresh idea for improving infertility.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2020.117830</identifier><identifier>PMID: 32450172</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Advanced glycation end products (AGEs) ; Advanced glycosylation end products ; Age ; Aging ; Diabetes mellitus ; DNA damage ; Glycosylation ; Infertility ; Kidney diseases ; Ovulatory dysfunction ; Oxidative stress ; Pathogenesis ; Senescence ; Sugar ; Vascular diseases</subject><ispartof>Life sciences (1973), 2020-08, Vol.255, p.117830-117830, Article 117830</ispartof><rights>2020</rights><rights>Copyright © 2020. Published by Elsevier Inc.</rights><rights>Copyright Elsevier BV Aug 15, 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-4f198b73b7b3ab30912ca4fc1aee831f136dedbcf31b8b08d2235a94a81447b53</citedby><cites>FETCH-LOGICAL-c447t-4f198b73b7b3ab30912ca4fc1aee831f136dedbcf31b8b08d2235a94a81447b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lfs.2020.117830$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32450172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Jing-ling</creatorcontrib><creatorcontrib>Cai, Ya-qin</creatorcontrib><creatorcontrib>Long, Shuang-lian</creatorcontrib><creatorcontrib>Chen, Zhuo</creatorcontrib><creatorcontrib>Mo, Zhong-cheng</creatorcontrib><title>The role of advanced glycation end products in human infertility</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Advanced glycation end products (AGEs) are heterogeneous products of the non-enzymatic interaction between proteins and reducing sugars. Numerous studies have shown that AGEs are associated with senescence, diabetes, vascular disease, aging and kidney disease. Infertility has been affected approximately 10 to15% of couples of reproductive ages. AGEs accumulation has been shown to play a crucial role in pathogenesis of infertility-related diseases. The present review provides the generation process, mechanism and pathological significance of AGEs and the novel treatment targeting AGEs for infertility.
[Display omitted]
•Increased exogenous AGEs intake and hyperglycemia and hyperlipidemia increased serum AGEs levels.•Elevated serum AGEs levels increase the risk of infertility.•AGEs damage male and female reproductive tract by increasing oxidative stress.•Treatments targeting AGE-RAGE system will provide a fresh idea for improving infertility.</description><subject>Advanced glycation end products (AGEs)</subject><subject>Advanced glycosylation end products</subject><subject>Age</subject><subject>Aging</subject><subject>Diabetes mellitus</subject><subject>DNA damage</subject><subject>Glycosylation</subject><subject>Infertility</subject><subject>Kidney diseases</subject><subject>Ovulatory dysfunction</subject><subject>Oxidative stress</subject><subject>Pathogenesis</subject><subject>Senescence</subject><subject>Sugar</subject><subject>Vascular diseases</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LJDEQhsPiso7u_gAv0uDFS89WJenpbrwo4hcIe5k9h3xUnAw93Zp0C_PvzTDqwYOnqoLnfSkexk4Q5gi4-Luedz7NOfB8Y90I-MFm2NRtCQuBB2wGwGUpOFSH7CilNQBUVS1-sUPBZQVY8xm7XK6oiENHxeAL7V51b8kVT93W6jEMfUG9K57j4CY7piL0xWra6D4vnuIYujBuf7OfXneJ_rzPY_b_9mZ5fV8-_rt7uL56LK2U9VhKj21jamFqI7QR0CK3WnqLmqgR6FEsHDljvUDTGGgc56LSrdQN5rypxDE73_fmb14mSqPahGSp63RPw5QUl7BoZS3bJqNnX9D1MMU-f6d4BZVEibArxD1l45BSJK-eY9jouFUIaqdXrVXWq3Z61V5vzpy-N09mQ-4z8eEzAxd7gLKK10BRJRto5zREsqNyQ_im_g3d0IkU</recordid><startdate>20200815</startdate><enddate>20200815</enddate><creator>Zhu, Jing-ling</creator><creator>Cai, Ya-qin</creator><creator>Long, Shuang-lian</creator><creator>Chen, Zhuo</creator><creator>Mo, Zhong-cheng</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20200815</creationdate><title>The role of advanced glycation end products in human infertility</title><author>Zhu, Jing-ling ; Cai, Ya-qin ; Long, Shuang-lian ; Chen, Zhuo ; Mo, Zhong-cheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-4f198b73b7b3ab30912ca4fc1aee831f136dedbcf31b8b08d2235a94a81447b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Advanced glycation end products (AGEs)</topic><topic>Advanced glycosylation end products</topic><topic>Age</topic><topic>Aging</topic><topic>Diabetes mellitus</topic><topic>DNA damage</topic><topic>Glycosylation</topic><topic>Infertility</topic><topic>Kidney diseases</topic><topic>Ovulatory dysfunction</topic><topic>Oxidative stress</topic><topic>Pathogenesis</topic><topic>Senescence</topic><topic>Sugar</topic><topic>Vascular diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Jing-ling</creatorcontrib><creatorcontrib>Cai, Ya-qin</creatorcontrib><creatorcontrib>Long, Shuang-lian</creatorcontrib><creatorcontrib>Chen, Zhuo</creatorcontrib><creatorcontrib>Mo, Zhong-cheng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Jing-ling</au><au>Cai, Ya-qin</au><au>Long, Shuang-lian</au><au>Chen, Zhuo</au><au>Mo, Zhong-cheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of advanced glycation end products in human infertility</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2020-08-15</date><risdate>2020</risdate><volume>255</volume><spage>117830</spage><epage>117830</epage><pages>117830-117830</pages><artnum>117830</artnum><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Advanced glycation end products (AGEs) are heterogeneous products of the non-enzymatic interaction between proteins and reducing sugars. Numerous studies have shown that AGEs are associated with senescence, diabetes, vascular disease, aging and kidney disease. Infertility has been affected approximately 10 to15% of couples of reproductive ages. AGEs accumulation has been shown to play a crucial role in pathogenesis of infertility-related diseases. The present review provides the generation process, mechanism and pathological significance of AGEs and the novel treatment targeting AGEs for infertility.
[Display omitted]
•Increased exogenous AGEs intake and hyperglycemia and hyperlipidemia increased serum AGEs levels.•Elevated serum AGEs levels increase the risk of infertility.•AGEs damage male and female reproductive tract by increasing oxidative stress.•Treatments targeting AGE-RAGE system will provide a fresh idea for improving infertility.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>32450172</pmid><doi>10.1016/j.lfs.2020.117830</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Life sciences (1973), 2020-08, Vol.255, p.117830-117830, Article 117830 |
| issn | 0024-3205 1879-0631 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Advanced glycation end products (AGEs) Advanced glycosylation end products Age Aging Diabetes mellitus DNA damage Glycosylation Infertility Kidney diseases Ovulatory dysfunction Oxidative stress Pathogenesis Senescence Sugar Vascular diseases |
| title | The role of advanced glycation end products in human infertility |
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