The role of advanced glycation end products in human infertility

Advanced glycation end products (AGEs) are heterogeneous products of the non-enzymatic interaction between proteins and reducing sugars. Numerous studies have shown that AGEs are associated with senescence, diabetes, vascular disease, aging and kidney disease. Infertility has been affected approximately 10 to15% of couples of reproductive ages. AGEs accumulation has been shown to play a crucial role in pathogenesis of infertility-related diseases. The present review provides the generation process, mechanism and pathological significance of AGEs and the novel treatment targeting AGEs for infertility. [Display omitted] •Increased exogenous AGEs intake and hyperglycemia and hyperlipidemia increased serum AGEs levels.•Elevated serum AGEs levels increase the risk of infertility.•AGEs damage male and female reproductive tract by increasing oxidative stress.•Treatments targeting AGE-RAGE system will provide a fresh idea for improving infertility.