Expressions of glutathione S‐transferase alpha, mu, pi, and theta in the skin samples of patients with acne rosacea

Background Data point to the importance of oxidative stress in rosacea. Glutathione S‐transferases (GSTs) have substantial roles in a wide variety of oxidative stress‐related conditions. Aim To evaluate the immunohistochemical staining characteristics of GST alpha (GSTA), mu (GSTM), pi (GSTP), and t...

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Veröffentlicht in:Journal of cosmetic dermatology 2020-08, Vol.19 (8), p.2070-2075
Hauptverfasser: Takci, Zennure, Gunes Bilgili, Serap, Kilic, Murat, Oguztuzun, Serpil, Bozer, Busra, Guler Simsek, Gulcin, Akbayrak, Atiye, Yıldız Seckin, Havva, Karadag, Ayse Serap
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Sprache:eng
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Zusammenfassung:Background Data point to the importance of oxidative stress in rosacea. Glutathione S‐transferases (GSTs) have substantial roles in a wide variety of oxidative stress‐related conditions. Aim To evaluate the immunohistochemical staining characteristics of GST alpha (GSTA), mu (GSTM), pi (GSTP), and theta (GSTT) in patients with rosacea. Patients/Methods The study included 23 women and 7 men with rosacea (mean ± SD age 49 ± 11 year) and 15 healthy control subjects (10 women, 5 men; mean ± SD age 47.86 ± 10.88 year). For each patient, the average disease duration, disease subtype, ocular involvement, and severity score were recorded. A 3‐mm punch biopsy was taken from the facial skin of each patient and control. Expression of GST isoenzymes was analyzed immunohistochemically. Results Expressions of GSTM1, GSTP1, and GSTT1 were significantly elevated in patients with rosacea compared to those in the control group (P = .0001, P = .0002, P 
ISSN:1473-2130
1473-2165
DOI:10.1111/jocd.13501