Editorial Commentary: Pulmonary Artery Denervation for Pulmonary Hypertension: Recent Updates and Future Perspectives

[...]multiple studies have demonstrated an activation of the sympathetic nervous system (SNS) in PH patients, which portends poor prognosis [5–8]. Despite the safety, efficacy and benefits of PADN reducing sympathetic dependent vasoconstriction, some phenomena remain perplexed, such as the technique's effect on fixed lesions in PH lungs. [...]as previously mentioned nerves supplying structures around the pulmonary trunk as well as cardiac autonomic chain and pulmonary parasympathetic supply are in close proximity to sympathetic nerves at the level of the main PA in PH. [...]PADN has become a novel intervention to treat various PH etiologies aiming to reduce the sympathetic activity of the pulmonary circulation.