Serology characteristics of SARS-CoV-2 infection after exposure and post-symptom onset
Timely diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a prerequisite for treatment and prevention. The serology characteristics and complement diagnosis value of the antibody test to RNA test need to be demonstrated. Serial sera of 80 patients with PCR-confirm...
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Veröffentlicht in: | The European respiratory journal 2020-08, Vol.56 (2), p.2000763 |
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creator | Lou, Bin Li, Ting-Dong Zheng, Shu-Fa Su, Ying-Ying Li, Zhi-Yong Liu, Wei Yu, Fei Ge, Sheng-Xiang Zou, Qian-Da Yuan, Quan Lin, Sha Hong, Cong-Ming Yao, Xiang-Yang Zhang, Xue-Jie Wu, Ding-Hui Zhou, Guo-Liang Hou, Wang-Heng Li, Ting-Ting Zhang, Ya-Li Zhang, Shi-Yin Fan, Jian Zhang, Jun Xia, Ning-Shao Chen, Yu |
description | Timely diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a prerequisite for treatment and prevention. The serology characteristics and complement diagnosis value of the antibody test to RNA test need to be demonstrated.
Serial sera of 80 patients with PCR-confirmed coronavirus disease 2019 (COVID-19) were collected at the First Affiliated Hospital of Zhejiang University, Hangzhou, China. Total antibody (Ab), IgM and IgG antibodies against SARS-CoV-2 were detected, and the antibody dynamics during the infection were described.
The seroconversion rates for Ab, IgM and IgG were 98.8%, 93.8% and 93.8%, respectively. The first detectible serology marker was Ab, followed by IgM and IgG, with a median seroconversion time of 15, 18 and 20 days post exposure (d.p.e.) or 9, 10 and 12 days post onset (d.p.o.), respectively. The antibody levels increased rapidly beginning at 6 d.p.o. and were accompanied by a decline in viral load. For patients in the early stage of illness (0-7 d.p.o), Ab showed the highest sensitivity (64.1%) compared with IgM and IgG (33.3% for both; p |
doi_str_mv | 10.1183/13993003.00763-2020 |
format | Article |
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Serial sera of 80 patients with PCR-confirmed coronavirus disease 2019 (COVID-19) were collected at the First Affiliated Hospital of Zhejiang University, Hangzhou, China. Total antibody (Ab), IgM and IgG antibodies against SARS-CoV-2 were detected, and the antibody dynamics during the infection were described.
The seroconversion rates for Ab, IgM and IgG were 98.8%, 93.8% and 93.8%, respectively. The first detectible serology marker was Ab, followed by IgM and IgG, with a median seroconversion time of 15, 18 and 20 days post exposure (d.p.e.) or 9, 10 and 12 days post onset (d.p.o.), respectively. The antibody levels increased rapidly beginning at 6 d.p.o. and were accompanied by a decline in viral load. For patients in the early stage of illness (0-7 d.p.o), Ab showed the highest sensitivity (64.1%) compared with IgM and IgG (33.3% for both; p<0.001). The sensitivities of Ab, IgM and IgG increased to 100%, 96.7% and 93.3%, respectively, 2 weeks later. When the same antibody type was detected, no significant difference was observed between enzyme-linked immunosorbent assays and other forms of immunoassays.
A typical acute antibody response is induced during SARS-CoV-2 infection. Serology testing provides an important complement to RNA testing in the later stages of illness for pathogenic-specific diagnosis and helpful information to evaluate the adapted immunity status of patients.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/13993003.00763-2020</identifier><identifier>PMID: 32430429</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Betacoronavirus ; China ; Clinical Laboratory Techniques ; Coronavirus Infections - blood ; Coronavirus Infections - complications ; Coronavirus Infections - diagnosis ; COVID-19 ; COVID-19 Testing ; Female ; Hospitalization ; Humans ; Infectious Disease Incubation Period ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral - blood ; Pneumonia, Viral - complications ; Pneumonia, Viral - diagnosis ; SARS-CoV-2 ; Sensitivity and Specificity ; Seroconversion ; Symptom Assessment ; Time Factors ; Viral Load</subject><ispartof>The European respiratory journal, 2020-08, Vol.56 (2), p.2000763</ispartof><rights>Copyright ©ERS 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-53ef2706cc0fb727828db457a8a3184cb7c7e5ec7039fc1501cf09578abb93c93</citedby><cites>FETCH-LOGICAL-c346t-53ef2706cc0fb727828db457a8a3184cb7c7e5ec7039fc1501cf09578abb93c93</cites><orcidid>0000-0003-3864-8446 ; 0000-0003-2536-1008</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32430429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lou, Bin</creatorcontrib><creatorcontrib>Li, Ting-Dong</creatorcontrib><creatorcontrib>Zheng, Shu-Fa</creatorcontrib><creatorcontrib>Su, Ying-Ying</creatorcontrib><creatorcontrib>Li, Zhi-Yong</creatorcontrib><creatorcontrib>Liu, Wei</creatorcontrib><creatorcontrib>Yu, Fei</creatorcontrib><creatorcontrib>Ge, Sheng-Xiang</creatorcontrib><creatorcontrib>Zou, Qian-Da</creatorcontrib><creatorcontrib>Yuan, Quan</creatorcontrib><creatorcontrib>Lin, Sha</creatorcontrib><creatorcontrib>Hong, Cong-Ming</creatorcontrib><creatorcontrib>Yao, Xiang-Yang</creatorcontrib><creatorcontrib>Zhang, Xue-Jie</creatorcontrib><creatorcontrib>Wu, Ding-Hui</creatorcontrib><creatorcontrib>Zhou, Guo-Liang</creatorcontrib><creatorcontrib>Hou, Wang-Heng</creatorcontrib><creatorcontrib>Li, Ting-Ting</creatorcontrib><creatorcontrib>Zhang, Ya-Li</creatorcontrib><creatorcontrib>Zhang, Shi-Yin</creatorcontrib><creatorcontrib>Fan, Jian</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Xia, Ning-Shao</creatorcontrib><creatorcontrib>Chen, Yu</creatorcontrib><title>Serology characteristics of SARS-CoV-2 infection after exposure and post-symptom onset</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>Timely diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a prerequisite for treatment and prevention. The serology characteristics and complement diagnosis value of the antibody test to RNA test need to be demonstrated.
Serial sera of 80 patients with PCR-confirmed coronavirus disease 2019 (COVID-19) were collected at the First Affiliated Hospital of Zhejiang University, Hangzhou, China. Total antibody (Ab), IgM and IgG antibodies against SARS-CoV-2 were detected, and the antibody dynamics during the infection were described.
The seroconversion rates for Ab, IgM and IgG were 98.8%, 93.8% and 93.8%, respectively. The first detectible serology marker was Ab, followed by IgM and IgG, with a median seroconversion time of 15, 18 and 20 days post exposure (d.p.e.) or 9, 10 and 12 days post onset (d.p.o.), respectively. The antibody levels increased rapidly beginning at 6 d.p.o. and were accompanied by a decline in viral load. For patients in the early stage of illness (0-7 d.p.o), Ab showed the highest sensitivity (64.1%) compared with IgM and IgG (33.3% for both; p<0.001). The sensitivities of Ab, IgM and IgG increased to 100%, 96.7% and 93.3%, respectively, 2 weeks later. When the same antibody type was detected, no significant difference was observed between enzyme-linked immunosorbent assays and other forms of immunoassays.
A typical acute antibody response is induced during SARS-CoV-2 infection. Serology testing provides an important complement to RNA testing in the later stages of illness for pathogenic-specific diagnosis and helpful information to evaluate the adapted immunity status of patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Betacoronavirus</subject><subject>China</subject><subject>Clinical Laboratory Techniques</subject><subject>Coronavirus Infections - blood</subject><subject>Coronavirus Infections - complications</subject><subject>Coronavirus Infections - diagnosis</subject><subject>COVID-19</subject><subject>COVID-19 Testing</subject><subject>Female</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Infectious Disease Incubation Period</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pandemics</subject><subject>Pneumonia, Viral - blood</subject><subject>Pneumonia, Viral - complications</subject><subject>Pneumonia, Viral - diagnosis</subject><subject>SARS-CoV-2</subject><subject>Sensitivity and Specificity</subject><subject>Seroconversion</subject><subject>Symptom Assessment</subject><subject>Time Factors</subject><subject>Viral Load</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF1LwzAUhoMobk5_gSC59CbzJKdtmssx_IKB4HS3Jc0SrbTNTFpw_97VbV6dw8vzngMPIdccppzneMdRKQTAKYDMkAkQcELGQ8qG-JSMQQEyrjAbkYsYvwB4liA_JyMUCUIi1Jisljb42n9sqfnUQZvOhip2lYnUO7qcvS7Z3K-YoFXrrOkq31Ltdgy1Pxsf-2Cpbtd0t3YsbptN5xvq22i7S3LmdB3t1WFOyPvD_dv8iS1eHp_nswUzmGQdS9E6ISEzBlwphcxFvi6TVOpcI88TU0ojbWqNBFTO8BS4caBSmeuyVGgUTsjt_u4m-O_exq5oqmhsXevW-j4WIoEUYdcbUNyjJvgYg3XFJlSNDtuCQzEILY5Ciz-hxSB017o5POjLxq7_O0eD-AsH4XBS</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Lou, Bin</creator><creator>Li, Ting-Dong</creator><creator>Zheng, Shu-Fa</creator><creator>Su, Ying-Ying</creator><creator>Li, Zhi-Yong</creator><creator>Liu, Wei</creator><creator>Yu, Fei</creator><creator>Ge, Sheng-Xiang</creator><creator>Zou, Qian-Da</creator><creator>Yuan, Quan</creator><creator>Lin, Sha</creator><creator>Hong, Cong-Ming</creator><creator>Yao, Xiang-Yang</creator><creator>Zhang, Xue-Jie</creator><creator>Wu, Ding-Hui</creator><creator>Zhou, Guo-Liang</creator><creator>Hou, Wang-Heng</creator><creator>Li, Ting-Ting</creator><creator>Zhang, Ya-Li</creator><creator>Zhang, Shi-Yin</creator><creator>Fan, Jian</creator><creator>Zhang, Jun</creator><creator>Xia, Ning-Shao</creator><creator>Chen, Yu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3864-8446</orcidid><orcidid>https://orcid.org/0000-0003-2536-1008</orcidid></search><sort><creationdate>20200801</creationdate><title>Serology characteristics of SARS-CoV-2 infection after exposure and post-symptom onset</title><author>Lou, Bin ; Li, Ting-Dong ; Zheng, Shu-Fa ; Su, Ying-Ying ; Li, Zhi-Yong ; Liu, Wei ; Yu, Fei ; Ge, Sheng-Xiang ; Zou, Qian-Da ; Yuan, Quan ; Lin, Sha ; Hong, Cong-Ming ; Yao, Xiang-Yang ; Zhang, Xue-Jie ; Wu, Ding-Hui ; Zhou, Guo-Liang ; Hou, Wang-Heng ; Li, Ting-Ting ; Zhang, Ya-Li ; Zhang, Shi-Yin ; Fan, Jian ; Zhang, Jun ; Xia, Ning-Shao ; Chen, Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-53ef2706cc0fb727828db457a8a3184cb7c7e5ec7039fc1501cf09578abb93c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Betacoronavirus</topic><topic>China</topic><topic>Clinical Laboratory Techniques</topic><topic>Coronavirus Infections - blood</topic><topic>Coronavirus Infections - complications</topic><topic>Coronavirus Infections - diagnosis</topic><topic>COVID-19</topic><topic>COVID-19 Testing</topic><topic>Female</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Infectious Disease Incubation Period</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pandemics</topic><topic>Pneumonia, Viral - blood</topic><topic>Pneumonia, Viral - complications</topic><topic>Pneumonia, Viral - diagnosis</topic><topic>SARS-CoV-2</topic><topic>Sensitivity and Specificity</topic><topic>Seroconversion</topic><topic>Symptom Assessment</topic><topic>Time Factors</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lou, Bin</creatorcontrib><creatorcontrib>Li, Ting-Dong</creatorcontrib><creatorcontrib>Zheng, Shu-Fa</creatorcontrib><creatorcontrib>Su, Ying-Ying</creatorcontrib><creatorcontrib>Li, Zhi-Yong</creatorcontrib><creatorcontrib>Liu, Wei</creatorcontrib><creatorcontrib>Yu, Fei</creatorcontrib><creatorcontrib>Ge, Sheng-Xiang</creatorcontrib><creatorcontrib>Zou, Qian-Da</creatorcontrib><creatorcontrib>Yuan, Quan</creatorcontrib><creatorcontrib>Lin, Sha</creatorcontrib><creatorcontrib>Hong, Cong-Ming</creatorcontrib><creatorcontrib>Yao, Xiang-Yang</creatorcontrib><creatorcontrib>Zhang, Xue-Jie</creatorcontrib><creatorcontrib>Wu, Ding-Hui</creatorcontrib><creatorcontrib>Zhou, Guo-Liang</creatorcontrib><creatorcontrib>Hou, Wang-Heng</creatorcontrib><creatorcontrib>Li, Ting-Ting</creatorcontrib><creatorcontrib>Zhang, Ya-Li</creatorcontrib><creatorcontrib>Zhang, Shi-Yin</creatorcontrib><creatorcontrib>Fan, Jian</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Xia, Ning-Shao</creatorcontrib><creatorcontrib>Chen, Yu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lou, Bin</au><au>Li, Ting-Dong</au><au>Zheng, Shu-Fa</au><au>Su, Ying-Ying</au><au>Li, Zhi-Yong</au><au>Liu, Wei</au><au>Yu, Fei</au><au>Ge, Sheng-Xiang</au><au>Zou, Qian-Da</au><au>Yuan, Quan</au><au>Lin, Sha</au><au>Hong, Cong-Ming</au><au>Yao, Xiang-Yang</au><au>Zhang, Xue-Jie</au><au>Wu, Ding-Hui</au><au>Zhou, Guo-Liang</au><au>Hou, Wang-Heng</au><au>Li, Ting-Ting</au><au>Zhang, Ya-Li</au><au>Zhang, Shi-Yin</au><au>Fan, Jian</au><au>Zhang, Jun</au><au>Xia, Ning-Shao</au><au>Chen, Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serology characteristics of SARS-CoV-2 infection after exposure and post-symptom onset</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>56</volume><issue>2</issue><spage>2000763</spage><pages>2000763-</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>Timely diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a prerequisite for treatment and prevention. The serology characteristics and complement diagnosis value of the antibody test to RNA test need to be demonstrated.
Serial sera of 80 patients with PCR-confirmed coronavirus disease 2019 (COVID-19) were collected at the First Affiliated Hospital of Zhejiang University, Hangzhou, China. Total antibody (Ab), IgM and IgG antibodies against SARS-CoV-2 were detected, and the antibody dynamics during the infection were described.
The seroconversion rates for Ab, IgM and IgG were 98.8%, 93.8% and 93.8%, respectively. The first detectible serology marker was Ab, followed by IgM and IgG, with a median seroconversion time of 15, 18 and 20 days post exposure (d.p.e.) or 9, 10 and 12 days post onset (d.p.o.), respectively. The antibody levels increased rapidly beginning at 6 d.p.o. and were accompanied by a decline in viral load. For patients in the early stage of illness (0-7 d.p.o), Ab showed the highest sensitivity (64.1%) compared with IgM and IgG (33.3% for both; p<0.001). The sensitivities of Ab, IgM and IgG increased to 100%, 96.7% and 93.3%, respectively, 2 weeks later. When the same antibody type was detected, no significant difference was observed between enzyme-linked immunosorbent assays and other forms of immunoassays.
A typical acute antibody response is induced during SARS-CoV-2 infection. Serology testing provides an important complement to RNA testing in the later stages of illness for pathogenic-specific diagnosis and helpful information to evaluate the adapted immunity status of patients.</abstract><cop>England</cop><pmid>32430429</pmid><doi>10.1183/13993003.00763-2020</doi><orcidid>https://orcid.org/0000-0003-3864-8446</orcidid><orcidid>https://orcid.org/0000-0003-2536-1008</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adult Aged Betacoronavirus China Clinical Laboratory Techniques Coronavirus Infections - blood Coronavirus Infections - complications Coronavirus Infections - diagnosis COVID-19 COVID-19 Testing Female Hospitalization Humans Infectious Disease Incubation Period Male Middle Aged Pandemics Pneumonia, Viral - blood Pneumonia, Viral - complications Pneumonia, Viral - diagnosis SARS-CoV-2 Sensitivity and Specificity Seroconversion Symptom Assessment Time Factors Viral Load |
title | Serology characteristics of SARS-CoV-2 infection after exposure and post-symptom onset |
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