Longitudinal Changes in Fat Mass and the Hippocampus

Longitudinal Changes in Fat Mass and the Hippocampus

Objective This study aimed to investigate cross‐sectional and longitudinal associations between fat mass (i.e., body mass index [BMI], waist circumference [WC], and waist to hip ratio [WTHR]) and hippocampal volumes. Methods UK Biobank participants (N = 20,395) aged 40 to 70 years (mean follow‐up = ...

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Veröffentlicht in:Obesity (Silver Spring, Md.) Md.), 2020-07, Vol.28 (7), p.1263-1269
Hauptverfasser: Ambikairajah, Ananthan, Tabatabaei‐Jafari, Hossein, Walsh, Erin, Hornberger, Michael, Cherbuin, Nicolas
Format: Artikel
Sprache:eng
Schlagworte:
Adipose Tissue - metabolism
Adipose Tissue - pathology
Adiposity - physiology
Adult
Aged
Body Mass Index
Cross-Sectional Studies
Female
Hippocampus - pathology
Humans
Ideal Body Weight - physiology
Longitudinal Studies
Male
Middle Aged
Obesity
Obesity - epidemiology
Obesity - metabolism
Obesity - pathology
Organ Size - physiology
Overweight - epidemiology
Overweight - metabolism
Overweight - pathology
Studies
United Kingdom - epidemiology
Waist Circumference
Waist-Hip Ratio
Womens health
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Beschreibung
Zusammenfassung:Objective This study aimed to investigate cross‐sectional and longitudinal associations between fat mass (i.e., body mass index [BMI], waist circumference [WC], and waist to hip ratio [WTHR]) and hippocampal volumes. Methods UK Biobank participants (N = 20,395) aged 40 to 70 years (mean follow‐up = 7.66 years), were included and categorized into one of four groups, which represented their baseline fat mass status and trajectory of change by follow‐up assessment: normal weight to overweight/obesity, overweight/obesity to normal weight (ON), normal weight stable (NS), or overweight/obesity stable (OS). Regression models used NS (WC 
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.22819