Pharmacological approaches to antibody‐mediated rejection—Are we getting closer?

Pharmacological approaches to antibody‐mediated rejection—Are we getting closer?

Animal research and initial clinical experience suggest that combined targeting of plasma cells and costimulation blockade effectively reduces the barrier of humoral immunity to organ transplants. See the article from Jain et al on page 2675.

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Bibliographische Detailangaben
Veröffentlicht in:American journal of transplantation 2020-10, Vol.20 (10), p.2637-2638
Hauptverfasser: Kwun, Jean, Knechtle, Stuart
Format: Artikel
Sprache:eng
Schlagworte:
Abatacept
alloantibody
animal models: nonhuman primate
Animals
Antibody Formation
Bortezomib
editorial/personal viewpoint
Graft rejection
Graft Rejection - drug therapy
Humans
Humoral immunity
immunosuppression/immune modulation
Kidney Transplantation
kidney transplantation/nephrology
Kidney transplants
Mice
Plasma cells
rejection: antibody‐mediated (ABMR)
Tissue Donors
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Beschreibung
Zusammenfassung:Animal research and initial clinical experience suggest that combined targeting of plasma cells and costimulation blockade effectively reduces the barrier of humoral immunity to organ transplants. See the article from Jain et al on page 2675.
ISSN:1600-6135
1600-6143
DOI:10.1111/ajt.16061