Gradient-based one-step fluorescence photoacoustic tomography

We propose a gradient-based scheme to solve the fluorescence photoacoustic tomographic (FPAT) problem in a fully nonlinear one-step setting, which aims to reconstruct the map of the absorption coefficient of an exogenous fluorophore from boundary photoacoustic pressure data. Adjoint-based gradient e...

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Veröffentlicht in:Applied optics (2004) 2020-05, Vol.59 (14), p.4357-4366
Hauptverfasser: Pandey, Prabodh Kumar, Gottam, Omprakash, Naik, Naren, Pradhan, Asima
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Sprache:eng
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Zusammenfassung:We propose a gradient-based scheme to solve the fluorescence photoacoustic tomographic (FPAT) problem in a fully nonlinear one-step setting, which aims to reconstruct the map of the absorption coefficient of an exogenous fluorophore from boundary photoacoustic pressure data. Adjoint-based gradient evaluation is presented for the FPAT problem in a frequency-domain photoacoustic equation setting. Numerical validations of the resulting Broyden-Fletcher-Goldfarb-Shanno (BFGS) reconstruction scheme are carried out in two dimensions for full-as well as limited-data test cases, and the results are compared with existing Jacobian-based one-step FPAT reconstructions. The reasonably comparable results of the one-step gradient- and Jacobian-based FPAT reconstruction schemes, coupled with the significant computational savings of the former, potentially set up the one-step gradient-based schemes as an advantageous method of choice for FPAT reconstructions. Further reconstruction studies carried out using quantitative photoacoustic tomography (QPAT)-based chromophore reconstructions as inputs to the FPAT inversions show a robustness of fluorophore absorption coefficient reconstructions to the QPAT-obtained inputs. (C) 2020 Optical Society of America
ISSN:1559-128X
2155-3165
1539-4522
DOI:10.1364/AO.382879