Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis

Problems and Pitfalls of Identifying Remyelination in Multiple Sclerosis

Regenerative medicines that promote remyelination in multiple sclerosis (MS) are making the transition from laboratory to clinical trials. While animal models provide the experimental flexibility to analyze mechanisms of remyelination, here we discuss the challenges in understanding where and how re...

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Veröffentlicht in:Cell stem cell 2020-05, Vol.26 (5), p.617-619
Hauptverfasser: Neumann, Bjoern, Foerster, Sarah, Zhao, Chao, Bodini, Benedetta, Reich, Daniel S., Bergles, Dwight E., Káradóttir, Ragnhildur Thóra, Lubetzki, Catherine, Lairson, Luke L., Zalc, Bernard, Stankoff, Bruno, Franklin, Robin J.M.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Models, Animal
Multiple Sclerosis - drug therapy
Myelin Sheath
Oligodendroglia
Regenerative Medicine
Remyelination
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Zusammenfassung:Regenerative medicines that promote remyelination in multiple sclerosis (MS) are making the transition from laboratory to clinical trials. While animal models provide the experimental flexibility to analyze mechanisms of remyelination, here we discuss the challenges in understanding where and how remyelination occurs in MS.
ISSN:1934-5909
1875-9777
DOI:10.1016/j.stem.2020.03.017