A Self-Organized PLT/Auxin/ARR-B Network Controls the Dynamics of Root Zonation Development in Arabidopsis thaliana

During organogenesis, coherent organ growth arises from spatiotemporally coordinated decisions of individual cells. In the root of Arabidopsis thaliana, this coordination results in the establishment of a division and a differentiation zone. Cells continuously move through these zones; thus, a major...

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Veröffentlicht in:Developmental cell 2020-05, Vol.53 (4), p.431-443.e23
Hauptverfasser: Salvi, Elena, Rutten, Jacob Pieter, Di Mambro, Riccardo, Polverari, Laura, Licursi, Valerio, Negri, Rodolfo, Dello Ioio, Raffaele, Sabatini, Sabrina, Ten Tusscher, Kirsten
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Sprache:eng
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Zusammenfassung:During organogenesis, coherent organ growth arises from spatiotemporally coordinated decisions of individual cells. In the root of Arabidopsis thaliana, this coordination results in the establishment of a division and a differentiation zone. Cells continuously move through these zones; thus, a major question is how the boundary between these domains, the transition zone, is formed and maintained. By combining molecular genetics with computational modeling, we reveal how an auxin/PLETHORA/ARR-B network controls these dynamic patterning processes. We show that after germination, cell division causes a drop in distal PLT2 levels that enables transition zone formation and ARR12 activation. The resulting PLT2-ARR12 antagonism controls expansion of the division zone (the meristem). The successive ARR1 activation antagonizes PLT2 through inducing the cell-cycle repressor KRP2, thus setting final meristem size. Our work indicates a key role for the interplay between cell division dynamics and regulatory networks in root zonation and transition zone patterning. [Display omitted] •Upon germination, cell divisions generate a PLT drop that forms the transition zone•A PLTs-ARR12 mutual antagonism restricts early root meristem expansion•ARR1 repression of cell division via KRP2 is key for meristem size stabilization•Auxin-PLTs-ARRs form a network responsible for self-organized root patterning How organs grow and stabilize when reaching a functional size is a central question in biology. Using the root of Arabidopsis as a model system and combining molecular genetics with computational modeling, Salvi et al. unveiled an auxin-PLTs-ARRs molecular network controlling the self-organized patterning of the root from germination onward.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2020.04.004