Thiol-responsive pro-fluorophore labeling: Synthesis of a pro-fluorescent labeled oligonucleotide for monitoring cellular uptake

Thiol-responsive pro-fluorophore labeling: Synthesis of a pro-fluorescent labeled oligonucleotide for monitoring cellular uptake

[Display omitted] Pro-fluorescent labeled oligonucleotides are potential alternative tools to classical fluorescently labeled oligonucleotides for monitoring cellular uptake. Here, we report the design and synthesis of a thiol-responsive pro-fluorophore labeled oligonucleotide, and its fluorescence...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2020-07, Vol.30 (13), p.127222-127222, Article 127222
Hauptverfasser: Saneyoshi, Hisao, Yamamoto, Yuta, Ohta, Takayuki, Akai, Shoji, Ono, Akira
Format: Artikel
Sprache:eng
Schlagworte:
Cellular uptake
Conjugation
Fluorogenic reaction
Oligonucleotides
Thiol
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Zusammenfassung:[Display omitted] Pro-fluorescent labeled oligonucleotides are potential alternative tools to classical fluorescently labeled oligonucleotides for monitoring cellular uptake. Here, we report the design and synthesis of a thiol-responsive pro-fluorophore labeled oligonucleotide, and its fluorescence responsivity to glutathione in the test tube and live cells.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2020.127222