Tau: A Novel Entry Point for mTOR-Based Treatments in Autism Spectrum Disorder?

Dysregulation of the PI3K/Akt/mTOR pathway has become a point of convergence in autism spectrum disorder (ASD). In this issue of Neuron, Tai et al. (2020) identify a therapeutic role for tau reduction in downregulating this pathway and ameliorating ASD-like symptoms. Dysregulation of the PI3K/Akt/mT...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2020-05, Vol.106 (3), p.359-361
Hauptverfasser:	Modi, Meera E., Sahin, Mustafa
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Autism Kinases Mutation Pathology Tau protein TOR protein
Online-Zugang:	Volltext
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Zusammenfassung:	Dysregulation of the PI3K/Akt/mTOR pathway has become a point of convergence in autism spectrum disorder (ASD). In this issue of Neuron, Tai et al. (2020) identify a therapeutic role for tau reduction in downregulating this pathway and ameliorating ASD-like symptoms. Dysregulation of the PI3K/Akt/mTOR pathway has become a point of convergence in autism spectrum disorder (ASD). In this issue of Neuron, Tai et al. (2020) identify a therapeutic role for tau reduction in downregulating this pathway and ameliorating ASD-like symptoms.
ISSN:	0896-6273 1097-4199
DOI:	10.1016/j.neuron.2020.04.019