Intragraft gene expression in native kidney BK virus nephropathy versus T cell–mediated rejection: Prospects for molecular diagnosis and risk prediction

Novel tools are needed to improve diagnostic accuracy and risk prediction in BK virus nephropathy (BKVN). We assessed the utility of intragraft gene expression testing for these purposes. Eight hundred genes were measured in 110 archival samples, including a discovery cohort of native kidney BKVN (n...

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Veröffentlicht in:	American journal of transplantation 2020-12, Vol.20 (12), p.3486-3501
Hauptverfasser:	Adam, Benjamin A., Kikic, Zeljko, Wagner, Siegfried, Bouatou, Yassine, Gueguen, Juliette, Drieux, Fanny, Reid, Graeme, Du, Katie, Bräsen, Jan H., D'Agati, Vivette D., Drachenberg, Cinthia B., Farkash, Evan A., Brad Farris, Alton, Geldenhuys, Laurette, Loupy, Alexandre, Nickeleit, Volker, Rabant, Marion, Randhawa, Parmjeet, Regele, Heinz, Mengel, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopsy BK Virus - genetics clinical research/ practice Gene Expression Graft rejection Graft Rejection - etiology Graft Rejection - genetics Humans Immune system Immunosuppression infection and infectious agents ‐ viral: BK/ JC/ polyoma infectious disease Kidney Kidney Diseases - diagnosis Kidney Diseases - genetics Kidney Transplantation - adverse effects kidney transplantation/ nephrology Kidney transplants Kidneys Lymphocytes T Medical diagnosis molecular biology: mRNA/ mRNA expression Nephropathy pathology/ histopathology Polyomavirus Infections - diagnosis Predictions rejection: T cell–mediated (TCMR) Risk Assessment T-Lymphocytes Tumor Virus Infections - diagnosis Viruses
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