Intragraft gene expression in native kidney BK virus nephropathy versus T cell–mediated rejection: Prospects for molecular diagnosis and risk prediction

Intragraft gene expression in native kidney BK virus nephropathy versus T cell–mediated rejection: Prospects for molecular diagnosis and risk prediction

Novel tools are needed to improve diagnostic accuracy and risk prediction in BK virus nephropathy (BKVN). We assessed the utility of intragraft gene expression testing for these purposes. Eight hundred genes were measured in 110 archival samples, including a discovery cohort of native kidney BKVN (n...

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Veröffentlicht in:American journal of transplantation 2020-12, Vol.20 (12), p.3486-3501
Hauptverfasser: Adam, Benjamin A., Kikic, Zeljko, Wagner, Siegfried, Bouatou, Yassine, Gueguen, Juliette, Drieux, Fanny, Reid, Graeme, Du, Katie, Bräsen, Jan H., D'Agati, Vivette D., Drachenberg, Cinthia B., Farkash, Evan A., Brad Farris, Alton, Geldenhuys, Laurette, Loupy, Alexandre, Nickeleit, Volker, Rabant, Marion, Randhawa, Parmjeet, Regele, Heinz, Mengel, Michael
Format: Artikel
Sprache:eng
Schlagworte:
Biopsy
BK Virus - genetics
clinical research/ practice
Gene Expression
Graft rejection
Graft Rejection - etiology
Graft Rejection - genetics
Humans
Immune system
Immunosuppression
infection and infectious agents ‐ viral: BK/ JC/ polyoma
infectious disease
Kidney
Kidney Diseases - diagnosis
Kidney Diseases - genetics
Kidney Transplantation - adverse effects
kidney transplantation/ nephrology
Kidney transplants
Kidneys
Lymphocytes T
Medical diagnosis
molecular biology: mRNA/ mRNA expression
Nephropathy
pathology/ histopathology
Polyomavirus Infections - diagnosis
Predictions
rejection: T cell–mediated (TCMR)
Risk Assessment
T-Lymphocytes
Tumor Virus Infections - diagnosis
Viruses
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Zusammenfassung:Novel tools are needed to improve diagnostic accuracy and risk prediction in BK virus nephropathy (BKVN). We assessed the utility of intragraft gene expression testing for these purposes. Eight hundred genes were measured in 110 archival samples, including a discovery cohort of native kidney BKVN (n = 5) vs pure T cell–mediated rejection (TCMR; n = 10). Five polyomavirus genes and seven immune‐related genes (five associated with BKVN and two associated with TCMR) were significantly differentially expressed between these entities (FDR 
ISSN:1600-6135
1600-6143
DOI:10.1111/ajt.15980