Metabolic effects of cholecalciferol supplementation in patients with calcium nephrolithiasis and vitamin D deficiency

Introduction In this paper, we investigated whether cholecalciferol supplementation may increase the risk of stone recurrence in patients with calcium nephrolithiasis and Vitamin D deficiency. Methods Thirty-three stone formers (56 ± 17 years old, 12 males) with 25(OH)D 1 mean supersaturation. Cholecalciferol was prescribed as oral bolus of 100,000–200,000 IU, followed by weekly (5000–10,000 IU) or monthly (25,000–50,000 IU) doses. Calcium intake varied between 800 and 1000 mg/day. In urine, total nitrogen (TNE) was taken as an index of protein intake, sodium as a marker of dietary intake, and net acid excretion (NAE) as an index of acid–base balance. Results TNE, sodium, and NAE did not change during the study ( p = ns). Compared to baseline values, after cholecalciferol, both serum calcium and phosphate did not vary ( p = ns); 25(OH)D increased from 11.8 ± 5.5 to 40.2 ± 12.2 ng/mL ( p