Evaluation of LDL receptor and Scavenger Receptor, Class B, Type 1 in the malignant and benign breast tumors: The correlation with the expression of miR-199a-5p, miR-199b-5p and miR-455-5p
•Receptor expressions and lipoproteins were higher in the breast cancer.•The expression of miR-199b-5p was downregulated in the malignant tumors.•Expression of miR-199a/b-5p and miR-455-5p were correlated with Her2 status.•A positive correlation was observed between SR-B1 or LDLR with HDL-C or LDL-C...
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| Veröffentlicht in: | Gene 2020-07, Vol.749, p.144720-144720, Article 144720 |
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| creator | Jamalzei, Behzad Karami Tehrani, Fatemeh Soghra Atri, Morteza |
| description | •Receptor expressions and lipoproteins were higher in the breast cancer.•The expression of miR-199b-5p was downregulated in the malignant tumors.•Expression of miR-199a/b-5p and miR-455-5p were correlated with Her2 status.•A positive correlation was observed between SR-B1 or LDLR with HDL-C or LDL-C.•The expression of miR-199b-5p was reversely associated with LDLR in the tumors.
The purpose of present study was to examine the correlations of LDL (LDLR) and HDL (SR-B1) receptors with lipoproteins, miR-199a-5p, miR-199b-5p, miR-455-5p in the malignant and benign breast tumors.
Total cholesterol-rich-lipoproteins and the receptors were determined using enzymatic-homogeneous and ELISA methods. The expression levels of miRNAs were detected by qRT-PCR.
Receptor expressions and lipoproteins concentration were significantly higher in the malignant tumors (p |
| doi_str_mv | 10.1016/j.gene.2020.144720 |
| format | Article |
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The purpose of present study was to examine the correlations of LDL (LDLR) and HDL (SR-B1) receptors with lipoproteins, miR-199a-5p, miR-199b-5p, miR-455-5p in the malignant and benign breast tumors.
Total cholesterol-rich-lipoproteins and the receptors were determined using enzymatic-homogeneous and ELISA methods. The expression levels of miRNAs were detected by qRT-PCR.
Receptor expressions and lipoproteins concentration were significantly higher in the malignant tumors (p < 0.05). Positive correlation was found for LDLR with Ki67% and Her2+. HDL-C content of TNBC tumors was higher than those of Non-TNBC (p < 0.05). The expression level of miR-199a-5p was found to be downregulated significantly in the malignant tumors of <2 cm, TNBC, HER2− or stage3. The expression of miR-199b-5p was downregulated in the malignant tumors and was negatively associated with TNBC, stage and Her2+. The expression of miR-455-5p was significantly correlated with Her2− (p < 0.05). A positive correlation was observed for SR-B1 or LDLR with HDL-C or LDL-C and also for SR-B1 with LDLR, although a reverse association was detected for the expression of miR-199b-5p with LDLR in the malignant tumors (p < 0.05). No significant correlations were found for miR-199a-5p or miR-455-5p with LDLR or SR-B1 expressions and also for LDL-C and SR-B1 with clinicopathological features (p ≥ 0.05).
Mechanisms potentially involved in the present findings may be due to the lipid internalization and lipoprotein consumption through LDLR and SR-B1 over expression. It is noteworthy that the expression of miR-199b-5p is negatively correlated with LDLR which may suggest it as a suppressor for LDLR expression in the breast cancer.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/j.gene.2020.144720</identifier><identifier>PMID: 32360840</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>LDLR ; Malignant breast tumors ; miR-199a-5p ; miR-199b-5p ; miR-455-5p ; SR-B1</subject><ispartof>Gene, 2020-07, Vol.749, p.144720-144720, Article 144720</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-ae2e3eb85eea4f51f1e8edf8fa6e67433fcb16fbde6924deac24d8b49717a2f13</citedby><cites>FETCH-LOGICAL-c356t-ae2e3eb85eea4f51f1e8edf8fa6e67433fcb16fbde6924deac24d8b49717a2f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.gene.2020.144720$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32360840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jamalzei, Behzad</creatorcontrib><creatorcontrib>Karami Tehrani, Fatemeh Soghra</creatorcontrib><creatorcontrib>Atri, Morteza</creatorcontrib><title>Evaluation of LDL receptor and Scavenger Receptor, Class B, Type 1 in the malignant and benign breast tumors: The correlation with the expression of miR-199a-5p, miR-199b-5p and miR-455-5p</title><title>Gene</title><addtitle>Gene</addtitle><description>•Receptor expressions and lipoproteins were higher in the breast cancer.•The expression of miR-199b-5p was downregulated in the malignant tumors.•Expression of miR-199a/b-5p and miR-455-5p were correlated with Her2 status.•A positive correlation was observed between SR-B1 or LDLR with HDL-C or LDL-C.•The expression of miR-199b-5p was reversely associated with LDLR in the tumors.
The purpose of present study was to examine the correlations of LDL (LDLR) and HDL (SR-B1) receptors with lipoproteins, miR-199a-5p, miR-199b-5p, miR-455-5p in the malignant and benign breast tumors.
Total cholesterol-rich-lipoproteins and the receptors were determined using enzymatic-homogeneous and ELISA methods. The expression levels of miRNAs were detected by qRT-PCR.
Receptor expressions and lipoproteins concentration were significantly higher in the malignant tumors (p < 0.05). Positive correlation was found for LDLR with Ki67% and Her2+. HDL-C content of TNBC tumors was higher than those of Non-TNBC (p < 0.05). The expression level of miR-199a-5p was found to be downregulated significantly in the malignant tumors of <2 cm, TNBC, HER2− or stage3. The expression of miR-199b-5p was downregulated in the malignant tumors and was negatively associated with TNBC, stage and Her2+. The expression of miR-455-5p was significantly correlated with Her2− (p < 0.05). A positive correlation was observed for SR-B1 or LDLR with HDL-C or LDL-C and also for SR-B1 with LDLR, although a reverse association was detected for the expression of miR-199b-5p with LDLR in the malignant tumors (p < 0.05). No significant correlations were found for miR-199a-5p or miR-455-5p with LDLR or SR-B1 expressions and also for LDL-C and SR-B1 with clinicopathological features (p ≥ 0.05).
Mechanisms potentially involved in the present findings may be due to the lipid internalization and lipoprotein consumption through LDLR and SR-B1 over expression. It is noteworthy that the expression of miR-199b-5p is negatively correlated with LDLR which may suggest it as a suppressor for LDLR expression in the breast cancer.</description><subject>LDLR</subject><subject>Malignant breast tumors</subject><subject>miR-199a-5p</subject><subject>miR-199b-5p</subject><subject>miR-455-5p</subject><subject>SR-B1</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kc2O0zAUhS0EYsrAC7BAXrJoOv5JnASxgTIwI1UaaShry3GuO64SJ9hOYd6Nh8NtOizxwta5OufY1ofQW0pWlFBxtV_twMGKEZYGeV4y8gwtaFXWGSG8eo4WhJdVRimtL9CrEPYkraJgL9EFZ1yQKicL9Of6oLpJRTs4PBi8-bLBHjSMcfBYuRZ_1-oAbgce35_HS7zuVAj48xJvH0fAFFuH4wPgXnV255SLp2ADLinceFAh4jj1gw8f8Db59OA9dPOVv2x8OIXh9-ghhPMzenuf0bpWWTEun0STxKn5qPOiSPI1emFUF-DN-bxEP75eb9c32ebu2-360ybTvBAxU8CAQ1MVACo3BTUUKmhNZZQAUeacG91QYZoWRM3yFpROe9XkdUlLxQzll-j93Dv64ecEIcreBg1dpxwMU5CM1xUVtKYiWdls1X4IwYORo7e98o-SEnmkJvfySE0eqcmZWgq9O_dPTQ_tv8gTpmT4OBsg_fJgwcugLTgNrU20omwH-7_-vx7AqGw</recordid><startdate>20200730</startdate><enddate>20200730</enddate><creator>Jamalzei, Behzad</creator><creator>Karami Tehrani, Fatemeh Soghra</creator><creator>Atri, Morteza</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200730</creationdate><title>Evaluation of LDL receptor and Scavenger Receptor, Class B, Type 1 in the malignant and benign breast tumors: The correlation with the expression of miR-199a-5p, miR-199b-5p and miR-455-5p</title><author>Jamalzei, Behzad ; Karami Tehrani, Fatemeh Soghra ; Atri, Morteza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-ae2e3eb85eea4f51f1e8edf8fa6e67433fcb16fbde6924deac24d8b49717a2f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>LDLR</topic><topic>Malignant breast tumors</topic><topic>miR-199a-5p</topic><topic>miR-199b-5p</topic><topic>miR-455-5p</topic><topic>SR-B1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jamalzei, Behzad</creatorcontrib><creatorcontrib>Karami Tehrani, Fatemeh Soghra</creatorcontrib><creatorcontrib>Atri, Morteza</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jamalzei, Behzad</au><au>Karami Tehrani, Fatemeh Soghra</au><au>Atri, Morteza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of LDL receptor and Scavenger Receptor, Class B, Type 1 in the malignant and benign breast tumors: The correlation with the expression of miR-199a-5p, miR-199b-5p and miR-455-5p</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>2020-07-30</date><risdate>2020</risdate><volume>749</volume><spage>144720</spage><epage>144720</epage><pages>144720-144720</pages><artnum>144720</artnum><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>•Receptor expressions and lipoproteins were higher in the breast cancer.•The expression of miR-199b-5p was downregulated in the malignant tumors.•Expression of miR-199a/b-5p and miR-455-5p were correlated with Her2 status.•A positive correlation was observed between SR-B1 or LDLR with HDL-C or LDL-C.•The expression of miR-199b-5p was reversely associated with LDLR in the tumors.
The purpose of present study was to examine the correlations of LDL (LDLR) and HDL (SR-B1) receptors with lipoproteins, miR-199a-5p, miR-199b-5p, miR-455-5p in the malignant and benign breast tumors.
Total cholesterol-rich-lipoproteins and the receptors were determined using enzymatic-homogeneous and ELISA methods. The expression levels of miRNAs were detected by qRT-PCR.
Receptor expressions and lipoproteins concentration were significantly higher in the malignant tumors (p < 0.05). Positive correlation was found for LDLR with Ki67% and Her2+. HDL-C content of TNBC tumors was higher than those of Non-TNBC (p < 0.05). The expression level of miR-199a-5p was found to be downregulated significantly in the malignant tumors of <2 cm, TNBC, HER2− or stage3. The expression of miR-199b-5p was downregulated in the malignant tumors and was negatively associated with TNBC, stage and Her2+. The expression of miR-455-5p was significantly correlated with Her2− (p < 0.05). A positive correlation was observed for SR-B1 or LDLR with HDL-C or LDL-C and also for SR-B1 with LDLR, although a reverse association was detected for the expression of miR-199b-5p with LDLR in the malignant tumors (p < 0.05). No significant correlations were found for miR-199a-5p or miR-455-5p with LDLR or SR-B1 expressions and also for LDL-C and SR-B1 with clinicopathological features (p ≥ 0.05).
Mechanisms potentially involved in the present findings may be due to the lipid internalization and lipoprotein consumption through LDLR and SR-B1 over expression. It is noteworthy that the expression of miR-199b-5p is negatively correlated with LDLR which may suggest it as a suppressor for LDLR expression in the breast cancer.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32360840</pmid><doi>10.1016/j.gene.2020.144720</doi><tpages>1</tpages></addata></record> |
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| subjects | LDLR Malignant breast tumors miR-199a-5p miR-199b-5p miR-455-5p SR-B1 |
| title | Evaluation of LDL receptor and Scavenger Receptor, Class B, Type 1 in the malignant and benign breast tumors: The correlation with the expression of miR-199a-5p, miR-199b-5p and miR-455-5p |
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