Manganese catalyst enables exploration of the magic methyl effect

The addition of a methyl group to a drug molecule can greatly alter the drug’s pharmacological properties. A catalyst has been developed that enables this ‘magic methyl effect’ to be rapidly explored for drug discovery. Late-stage functionalization of complex organic molecules.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 2020-04, Vol.580 (7805), p.592-593
Hauptverfasser:	Corcoran, Emily B., Schultz, Danielle M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154 639/638 639/638/403 639/638/549 Analysis Atomic properties Drugs Influence Manganese Materials Metal catalysts Methyl groups News And Views
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The addition of a methyl group to a drug molecule can greatly alter the drug’s pharmacological properties. A catalyst has been developed that enables this ‘magic methyl effect’ to be rapidly explored for drug discovery. Late-stage functionalization of complex organic molecules.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/d41586-020-01167-1