Ruthenium-catalyzed synthesis of vinylamides at low acetylene pressure

Ruthenium-catalyzed synthesis of vinylamides at low acetylene pressure

The reaction of cyclic amides with acetylene under low pressure, using ruthenium-phosphine catalysts, afforded a broad variety of N -vinylated amides including (azabicyclic) lactams, oxazolidinones, benzoisoxazolones, isoindolinones, quinoxalinones, oxazinanones, cyclic urea derivatives (imidazolidi...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-06, Vol.56 (44), p.5977-598
Hauptverfasser: Semina, Elena, Tuzina, Pavel, Bienewald, Frank, Hashmi, A. Stephen K, Schaub, Thomas
Format: Artikel
Sprache:eng
Schlagworte:
Acetylene
Acidic oxides
Amides
Chemical synthesis
Low pressure
Phosphines
Ruthenium
Thymine
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Zusammenfassung:The reaction of cyclic amides with acetylene under low pressure, using ruthenium-phosphine catalysts, afforded a broad variety of N -vinylated amides including (azabicyclic) lactams, oxazolidinones, benzoisoxazolones, isoindolinones, quinoxalinones, oxazinanones, cyclic urea derivatives (imidazolidinones), nucleobases (thymine), amino acid anhydrides and thiazolidinone. Going mild: vinylations of cyclic amides with C 2 H 2 using Ru-phosphine catalysts.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc01533d