Quantification of liver extracellular volume using dual-energy CT: utility for prediction of liver-related events in cirrhosis

Objectives To determine whether quantification of liver extracellular volume fraction (fECV) using dual-energy CT (DECT) allows prediction of liver-related events (LREs) in cirrhotic patients. Methods This retrospective study included 305 cirrhotic patients who underwent dual-source DECT imaging and...

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Veröffentlicht in:	European radiology 2020-10, Vol.30 (10), p.5317-5326
Hauptverfasser:	Bak, Seongjun, Kim, Ji Eun, Bae, Kyungsoo, Cho, Jae Min, Choi, Ho Cheol, Park, Mi Jung, Choi, Hye Young, Shin, Hwa Seon, Lee, Sang Min, Kim, Hyun Ok
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Albumin Cirrhosis Computed tomography Confidence intervals Contrast Media Diagnostic Radiology Energy Extracellular Space - diagnostic imaging Female Hepatobiliary-Pancreas Hepatocellular carcinoma Humans Image contrast Imaging Internal Medicine Interventional Radiology Iodine Liver Liver - diagnostic imaging Liver cancer Liver cirrhosis Liver Cirrhosis - complications Liver Cirrhosis - diagnosis Liver diseases Liver Neoplasms - diagnosis Liver Neoplasms - etiology Male Markers Medical imaging Medicine Medicine & Public Health Middle Aged Neuroradiology Predictions Prognosis Radiology Retrospective Studies Risk groups Serum albumin Tomography, X-Ray Computed - methods Ultrasound
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Zusammenfassung:	Objectives To determine whether quantification of liver extracellular volume fraction (fECV) using dual-energy CT (DECT) allows prediction of liver-related events (LREs) in cirrhotic patients. Methods This retrospective study included 305 cirrhotic patients who underwent dual-source DECT imaging and had serum markers analyzed within 2 weeks of initial CT imaging. The fECV score was measured using an iodine map of equilibrium-phase images obtained 3 min after contrast injection at 100/140 Sn kVp. The association of the fECV score and serum markers with LREs was investigated. A risk model combining the fECV score (
ISSN:	0938-7994 1432-1084
DOI:	10.1007/s00330-020-06876-9