Flavin doesn’t put all oxygens in one basket

Flavin doesn’t put all oxygens in one basket

Oxygen activation mechanisms catalyzed by flavin cofactors are established for electron transfer (oxidases) and C4a covalent flavin–oxygen adduct formation (oxygen-inserting monooxygenases). A new paradigm for oxygen insertion involving a flavin-N5-aminoperoxide intermediate has now been discovered...

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Veröffentlicht in:Nature chemical biology 2020-05, Vol.16 (5), p.485-486
Hauptverfasser: Leys, David, Scrutton, Nigel S.
Format: Artikel
Sprache:eng
Schlagworte:
631/535/1266
631/92/173
631/92/607
Biochemical Engineering
Biochemistry
Bioorganic Chemistry
Catalysis
Cell Biology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cofactors
Electron transfer
Flavin
Flavins
Mixed Function Oxygenases
News & Views
news-and-views
Oxygen
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Beschreibung
Zusammenfassung:Oxygen activation mechanisms catalyzed by flavin cofactors are established for electron transfer (oxidases) and C4a covalent flavin–oxygen adduct formation (oxygen-inserting monooxygenases). A new paradigm for oxygen insertion involving a flavin-N5-aminoperoxide intermediate has now been discovered in select flavin-dependent monooxygenases.
ISSN:1552-4450
1552-4469
DOI:10.1038/s41589-020-0523-z