CD4/CD8 ratio, comorbidities, and aging in treated HIV infected individuals on viral suppression

The progression of the human immunodeficiency virus (HIV) infection to acquired immunodeficiency syndrome (AIDS) can be efficiently interrupted by antiretroviral therapy (ART). However, even successfully treated HIV‐infected individuals are prone to develop non‐AIDS‐related diseases that affect the metabolism and several organs and systems. Biomarkers that predict the occurrence of comorbidities may help develop preventive measures. Current research shows that CD4+ T cell counts and viral load do not predict the development of non‐AIDS‐related diseases. The CD4/CD8 ratio has been indicated as a suitable marker of persistent immune dysfunction and the occurrence of non‐AIDS‐related events in treated HIV‐positive patients. In this study, we explored the relationship between CD4/CD8 ratios, comorbidities, and aging in ART‐treated HIV patients on viral suppression. We collected and evaluated data from 352 HIV‐positive adults who were virologically suppressed (