Retrospective analysis of long‐term outcome 10 years after liver transplantation for Wilson disease: experience over three decades

Summary We evaluated long‐term outcomes for patients with Wilson disease (WD) after liver transplantation (LT) and searched for risk factors for poor survival. Retrospective analysis of UNOS/OPTN data identified 156 pediatric and 515 adult cases of LT for WD between 1987 and 2016. Comparison cases w...

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Veröffentlicht in:	Transplant international 2020-08, Vol.33 (8), p.925-935
Hauptverfasser:	Ismail, Mohamed Saleh, Hassan, Manal, Martinez‐Camacho, Alvaro, May, Sarah B, Goss, John A, Kanwal, Fasiha, Jalal, Prasun K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Creatinine Gender graft survival Liver Liver diseases Liver transplantation Liver transplants Mathematical analysis patient survival Pediatrics Regression analysis Risk analysis Risk factors standard transplant analysis and research Survival Transplantation Transplants & implants United Network for Organ Sharing Wilson disease Wilson's disease
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Zusammenfassung:	Summary We evaluated long‐term outcomes for patients with Wilson disease (WD) after liver transplantation (LT) and searched for risk factors for poor survival. Retrospective analysis of UNOS/OPTN data identified 156 pediatric and 515 adult cases of LT for WD between 1987 and 2016. Comparison cases were 10 442 pediatric and 104 874 adult non‐WD transplant recipients. Survival was calculated using Kaplan–Meier analysis. Recipient, donor, and surgical variables were compared by Cox regression. Survival rates 3, 5, and 10 years after LT for adult WD patients (87.5%, 85.4%, and 80.5%, respectively) were significantly higher than those for non‐WD patients (P
ISSN:	0934-0874 1432-2277
DOI:	10.1111/tri.13622