Management of viral hepatitis A, C, D and E in pregnancy

Viral hepatitis can cause significant maternal and neonatal morbidity and mortality. Hepatitis A and E mainly present as acute hepatitis during pregnancy, while hepatitis C and D are usually found as chronic infection in pregnant women. Hepatitis A remains self-limiting during pregnancy while hepatitis E has a higher prevalence and manifests with a rigorous course in pregnant women. Screening of hepatitis C during pregnancy and its subsequent management during pregnancy are still a debatable topic. New treatments of hepatitis C and E require further evaluation for use in pregnancy. This review summarizes the prevalence, clinical manifestations, maternal, foetal and neonatal effects, and the management of hepatitis A, C, D and E viral infection during pregnancy. •Viral hepatitis infection during pregnancy is not uncommon.•Vertical transmission of hepatitis A, C, D and E is possible.•Treatment of acute hepatitis during pregnancy remains supportive.•Extensive research is needed on direct-acting antivirals during pregnancy and lactation.•Breastfeeding should be encouraged for women infected with hepatitis A, C and D.