Osteoclast stimulatory transmembrane protein (OC‐STAMP) is a promising molecular prognostic indicator for multiple myeloma

Background Currently, the prognostic stratification and therapeutic evaluation systems for multiple myeloma (MM) lack specific molecular indicators. OC‐STAMP is a new gene and is also highly expressed in MM. Methods A total of 160 MM patients have been investigated with both quantitative reverse transcription PCR (RT‐qPCR), flow cytometry (FCM) and cytogenetic FISH on the same mononuclear cells isolated from bone marrow specimens. Results We found that OC‐STAMP mRNA levels were significantly higher in newly diagnosed cases of MM than in healthy donors (median, 0.52% vs. 0.02%, P