Measurement of Typhim Vi® IgG antibodies in healthy donors as a tool for the diagnostic of patients with antibody deficiencies

Measurement of Typhim Vi® IgG antibodies in healthy donors as a tool for the diagnostic of patients with antibody deficiencies

•Immune response to polysaccharides is critical in humoral immunodeficiencies diagnosis.•Basal IgG to S. thyphi is a key aspect to use this neoantigen in different populations.•Quantification of the boost induced by vaccination in healthy population is fundamental.•Results obtained reinforce its use...

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Veröffentlicht in:Clinical immunology (Orlando, Fla.) Fla.), 2020-06, Vol.215, p.108416-108416, Article 108416
Hauptverfasser: Barrios, Y., Franco, A., Alonso-Larruga, A., García, C., Suarez-Toste, I., Sánchez-Machín, I., Rivera-Dean, A., Garcia-Marín, N.M., Guerra-Neira, A., Matheu, V.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Antibodies, Bacterial - immunology
Female
Humans
Immunoglobulin G - immunology
Male
Middle Aged
Polysaccharides, Bacterial - immunology
Primary Immunodeficiency Diseases - diagnosis
Tissue Donors
Typhoid-Paratyphoid Vaccines - immunology
Young Adult
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Beschreibung
Zusammenfassung:•Immune response to polysaccharides is critical in humoral immunodeficiencies diagnosis.•Basal IgG to S. thyphi is a key aspect to use this neoantigen in different populations.•Quantification of the boost induced by vaccination in healthy population is fundamental.•Results obtained reinforce its use in our geographical area with diagnosis purposes.
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2020.108416