Ageing and cognition in men with fragile X syndrome

Ageing and cognition in men with fragile X syndrome

Background Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. The aim of our longitudinal study was to describe ageing‐related cognitive changes in men with FXS. Method A neuropsychologist determined the raw scores (RSs) of 19 men with FXS twice with the Leiter I...

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Veröffentlicht in:Journal of applied research in intellectual disabilities 2020-09, Vol.33 (5), p.1113-1118
Hauptverfasser: Sauna‐aho, Oili, Bjelogrlic‐Laakso, Nina, Rautava, Päivi, Arvio, Maria
Format: Artikel
Sprache:eng
Schlagworte:
Adolescents
Adults
ageing
Aging
Aging (Individuals)
Cognitive Ability
cognitive development
fragile X syndrome
Genetic disorders
Intellectual disabilities
Intellectual Disability
Longitudinal Studies
Males
Mens health
Neuropsychology
Older people
Raw Scores
Schemata (Cognition)
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Zusammenfassung:Background Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. The aim of our longitudinal study was to describe ageing‐related cognitive changes in men with FXS. Method A neuropsychologist determined the raw scores (RSs) of 19 men with FXS twice with the Leiter International Performance Scale at an average interval of 22 years. The ages of the participants at baseline ranged from 16 to 50 (mean 27) years. Results At follow‐up, the RSs improved in two men, remained the same in two men and declined in 15 men. Overall, the RS of the study group deteriorated by an average 4 points in RSs (p 
ISSN:1360-2322
1468-3148
DOI:10.1111/jar.12733