Tumor Progression of Breast Cancer during Hyperinsulinemic Obesity

Factors of metabolic syndrome including hyperinsulinemia and obesity are well known to increase the risk of cancer incidence and progression. In a recent iScience article, Ramos et al. demonstrate a novel tumor-suppressor role of the circadian transcription factor BMAL1 in triple-negative breast can...

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Veröffentlicht in:	Trends in molecular medicine 2020-04, Vol.26 (4), p.354-356
Hauptverfasser:	Boese, Austin C., Kang, Sumin
Format:	Artikel
Sprache:	eng
Schlagworte:	BMAL1 insulin treatment metabolism obesity triple-negative breast cancer tumor suppressor
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Factors of metabolic syndrome including hyperinsulinemia and obesity are well known to increase the risk of cancer incidence and progression. In a recent iScience article, Ramos et al. demonstrate a novel tumor-suppressor role of the circadian transcription factor BMAL1 in triple-negative breast cancer (TNBC) specifically under conditions of hyperinsulinemia.
ISSN:	1471-4914 1471-499X
DOI:	10.1016/j.molmed.2020.01.014