Local White Matter Fiber Clustering Differentiates Parkinson’s Disease Diagnoses

•Application of AAFC to study PD and SWEDD in subdivisions of white matter tracts.•Diffusion metrics correlate with the cognitive and motor clinical scores.•Microstructural changes in the cingulum bundle tract can characterize SWEDD from PD.•Differences in subdivisions of white matter tracts can classify PD and SWEDD. Scans without evidence of dopaminergic deficit (SWEDD) patients are often misdiagnosed with Parkinson’s disease (PD) but have normal dopamine transporter scans. We hypothesised that white matter tracts associated with motor and cognition functions may be affected differently by SWEDD and PD. Automatically annotated fibre clustering (AAFC) is a novel clustering method based on diffusion magnetic resonance imaging (dMRI) tractography that enables highly robust reconstruction of white matter tracts that are composed of corresponding clusters. This study aimed to investigate the white matter properties in the subdivisions of white matter tracts among SWEDD and PD groups. We applied AAFC to identify white matter tracts related to motion and cognition functions in the dataset consisting of SWEDD (n = 22), PD (n = 30) and normal control (NC) (n = 30). Then, we resampled 200 nodes along fibres of cluster, and the diffusion metric values corresponding to each node were calculated and used for comparison. Compared with NC, PD showed significant difference (p