Microarc oxidation surface of titanium implants promote osteogenic differentiation by activating ERK1/2-miR-1827-Osterix

There has been a constant requirement from the clinic to develop biomédical titanium (Ti) implants with high osteogenic ability. In this study, we clarified a novel mechanism of how MAO (microarc oxidation) coating of Ti implants facilitates osteogenic differentiation of human bone marrow mesenchyma...

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Veröffentlicht in:	In vitro cellular & developmental biology. Animal 2020-04, Vol.56 (4), p.296-306
Hauptverfasser:	Liu, Liu, Zeng, Da, Chen, Yanwen, Zhou, Junbo, Liao, Yunyang, Shi, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipogenesis - drug effects Adipogenesis - genetics Animal Genetics and Genomics Biomedical and Life Sciences Biomedical materials BIOTECHNOLOGY Bone implants Bone marrow Cell Biology Cell Culture Cell Differentiation - drug effects Cell Differentiation - genetics Coating Coatings Developmental Biology Differentiation (biology) Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Humans Life Sciences MAP kinase Mesenchymal stem cells Mesenchyme MicroRNAs - genetics MicroRNAs - metabolism Osteogenesis Osteogenesis - drug effects Osteogenesis - genetics Osteolysis Oxidation Oxidation-Reduction p38 Mitogen-Activated Protein Kinases - metabolism Prostheses and Implants Signal transduction Sp7 Transcription Factor - metabolism Stem Cells Surgical implants Titanium Titanium - pharmacology Transplants & implants
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