Microarc oxidation surface of titanium implants promote osteogenic differentiation by activating ERK1/2-miR-1827-Osterix
There has been a constant requirement from the clinic to develop biomédical titanium (Ti) implants with high osteogenic ability. In this study, we clarified a novel mechanism of how MAO (microarc oxidation) coating of Ti implants facilitates osteogenic differentiation of human bone marrow mesenchyma...
Gespeichert in:
| Veröffentlicht in: | In vitro cellular & developmental biology. Animal 2020-04, Vol.56 (4), p.296-306 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 306 |
|---|---|
| container_issue | 4 |
| container_start_page | 296 |
| container_title | In vitro cellular & developmental biology. Animal |
| container_volume | 56 |
| creator | Liu, Liu Zeng, Da Chen, Yanwen Zhou, Junbo Liao, Yunyang Shi, Bin |
| description | There has been a constant requirement from the clinic to develop biomédical titanium (Ti) implants with high osteogenic ability. In this study, we clarified a novel mechanism of how MAO (microarc oxidation) coating of Ti implants facilitates osteogenic differentiation of human bone marrow mesenchymal stem cells (hB-MSCs) by activating ERKl/2-miR-1827-Osterix signaling pathway in vitro. MAO surface of titanium implant was more favorable to promote osteogenic differentiation than SLA and AOS coating. Besides, titanium implants regulated hB-MSCs osteogenesis through the p38 MAPK pathway and ERK1/2 might be the most efficient target. Furthermore, MAO coating induced osteogenic differentiation though ERK1/2-miR-1827 pathway. Finally, we verified miR-1827 regulated osteogenic differentiation partially through Osterix. Our study reveals novel insights that MAO surface of titanium implant is a prior choice for biomédical trial and for its use in periprosthetic osteolysis (PIO) treatment in an evidence-based rationale. |
| doi_str_mv | 10.1007/s11626-020-00444-7 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2388003228</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>45295973</jstor_id><sourcerecordid>45295973</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-484a98c5214748778096be687db419dadc9a5c80f5257e2b4fc1f581dc131b723</originalsourceid><addsrcrecordid>eNp9kU1rFTEUhgdRbK3-ARcyIIKb2HPyMUmWUuoHVgpFwV3IZDKXXO5MrklGbv99Y6dqcdFsknCe983JeZvmJcI7BJCnGbGjHQEKBIBzTuSj5hgFZ0RC9-NxPYNEQjsNR82znLdQl8buaXPEKJXANB43h6_BpWiTa-MhDLaEOLd5SaN1vo1jW0Kxc1imNkz7nZ1LbvcpTrHUYi4-bvwcXDuEcfTJzyWs-v66ta6EX_U2b9rzqy94SskUrggqKsllFaZweN48Ge0u-xd3-0nz_cP5t7NP5OLy4-ez9xfEcRCFcMWtVk5Q5JIrKRXorvedkkPPUQ92cNoKp2AUVEhPez46HIXCwSHDXlJ20rxdfWvjPxefi5lCdn5Xf-Pjkg1lSgHUgaiKvv4P3cYlzbU7QzlS7DiTXaXoStW55Zz8aPYpTDZdGwTzOxez5mJqLuY2FyOr6NWd9dJPfvgr-RNEBdgK5FqaNz79e_tB2zeraptLTPcboawquKBaaMnYDeRno48</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2412164376</pqid></control><display><type>article</type><title>Microarc oxidation surface of titanium implants promote osteogenic differentiation by activating ERK1/2-miR-1827-Osterix</title><source>JSTOR Archive Collection A-Z Listing</source><source>MEDLINE</source><source>Springer Online Journals Complete</source><creator>Liu, Liu ; Zeng, Da ; Chen, Yanwen ; Zhou, Junbo ; Liao, Yunyang ; Shi, Bin</creator><creatorcontrib>Liu, Liu ; Zeng, Da ; Chen, Yanwen ; Zhou, Junbo ; Liao, Yunyang ; Shi, Bin</creatorcontrib><description>There has been a constant requirement from the clinic to develop biomédical titanium (Ti) implants with high osteogenic ability. In this study, we clarified a novel mechanism of how MAO (microarc oxidation) coating of Ti implants facilitates osteogenic differentiation of human bone marrow mesenchymal stem cells (hB-MSCs) by activating ERKl/2-miR-1827-Osterix signaling pathway in vitro. MAO surface of titanium implant was more favorable to promote osteogenic differentiation than SLA and AOS coating. Besides, titanium implants regulated hB-MSCs osteogenesis through the p38 MAPK pathway and ERK1/2 might be the most efficient target. Furthermore, MAO coating induced osteogenic differentiation though ERK1/2-miR-1827 pathway. Finally, we verified miR-1827 regulated osteogenic differentiation partially through Osterix. Our study reveals novel insights that MAO surface of titanium implant is a prior choice for biomédical trial and for its use in periprosthetic osteolysis (PIO) treatment in an evidence-based rationale.</description><identifier>ISSN: 1071-2690</identifier><identifier>EISSN: 1543-706X</identifier><identifier>DOI: 10.1007/s11626-020-00444-7</identifier><identifier>PMID: 32270391</identifier><language>eng</language><publisher>New York: Springer Science & Business Media LLC</publisher><subject>Adipogenesis - drug effects ; Adipogenesis - genetics ; Animal Genetics and Genomics ; Biomedical and Life Sciences ; Biomedical materials ; BIOTECHNOLOGY ; Bone implants ; Bone marrow ; Cell Biology ; Cell Culture ; Cell Differentiation - drug effects ; Cell Differentiation - genetics ; Coating ; Coatings ; Developmental Biology ; Differentiation (biology) ; Extracellular signal-regulated kinase ; Extracellular Signal-Regulated MAP Kinases - metabolism ; Humans ; Life Sciences ; MAP kinase ; Mesenchymal stem cells ; Mesenchyme ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Osteogenesis ; Osteogenesis - drug effects ; Osteogenesis - genetics ; Osteolysis ; Oxidation ; Oxidation-Reduction ; p38 Mitogen-Activated Protein Kinases - metabolism ; Prostheses and Implants ; Signal transduction ; Sp7 Transcription Factor - metabolism ; Stem Cells ; Surgical implants ; Titanium ; Titanium - pharmacology ; Transplants & implants</subject><ispartof>In vitro cellular & developmental biology. Animal, 2020-04, Vol.56 (4), p.296-306</ispartof><rights>2020 Society for in Vitro Biology</rights><rights>The Society for In Vitro Biology 2020</rights><rights>The Society for In Vitro Biology 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-484a98c5214748778096be687db419dadc9a5c80f5257e2b4fc1f581dc131b723</citedby><cites>FETCH-LOGICAL-c405t-484a98c5214748778096be687db419dadc9a5c80f5257e2b4fc1f581dc131b723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/45295973$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/45295973$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,41464,42533,51294,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32270391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Liu</creatorcontrib><creatorcontrib>Zeng, Da</creatorcontrib><creatorcontrib>Chen, Yanwen</creatorcontrib><creatorcontrib>Zhou, Junbo</creatorcontrib><creatorcontrib>Liao, Yunyang</creatorcontrib><creatorcontrib>Shi, Bin</creatorcontrib><title>Microarc oxidation surface of titanium implants promote osteogenic differentiation by activating ERK1/2-miR-1827-Osterix</title><title>In vitro cellular & developmental biology. Animal</title><addtitle>In Vitro Cell.Dev.Biol.-Animal</addtitle><addtitle>In Vitro Cell Dev Biol Anim</addtitle><description>There has been a constant requirement from the clinic to develop biomédical titanium (Ti) implants with high osteogenic ability. In this study, we clarified a novel mechanism of how MAO (microarc oxidation) coating of Ti implants facilitates osteogenic differentiation of human bone marrow mesenchymal stem cells (hB-MSCs) by activating ERKl/2-miR-1827-Osterix signaling pathway in vitro. MAO surface of titanium implant was more favorable to promote osteogenic differentiation than SLA and AOS coating. Besides, titanium implants regulated hB-MSCs osteogenesis through the p38 MAPK pathway and ERK1/2 might be the most efficient target. Furthermore, MAO coating induced osteogenic differentiation though ERK1/2-miR-1827 pathway. Finally, we verified miR-1827 regulated osteogenic differentiation partially through Osterix. Our study reveals novel insights that MAO surface of titanium implant is a prior choice for biomédical trial and for its use in periprosthetic osteolysis (PIO) treatment in an evidence-based rationale.</description><subject>Adipogenesis - drug effects</subject><subject>Adipogenesis - genetics</subject><subject>Animal Genetics and Genomics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical materials</subject><subject>BIOTECHNOLOGY</subject><subject>Bone implants</subject><subject>Bone marrow</subject><subject>Cell Biology</subject><subject>Cell Culture</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Differentiation - genetics</subject><subject>Coating</subject><subject>Coatings</subject><subject>Developmental Biology</subject><subject>Differentiation (biology)</subject><subject>Extracellular signal-regulated kinase</subject><subject>Extracellular Signal-Regulated MAP Kinases - metabolism</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>MAP kinase</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchyme</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Osteogenesis</subject><subject>Osteogenesis - drug effects</subject><subject>Osteogenesis - genetics</subject><subject>Osteolysis</subject><subject>Oxidation</subject><subject>Oxidation-Reduction</subject><subject>p38 Mitogen-Activated Protein Kinases - metabolism</subject><subject>Prostheses and Implants</subject><subject>Signal transduction</subject><subject>Sp7 Transcription Factor - metabolism</subject><subject>Stem Cells</subject><subject>Surgical implants</subject><subject>Titanium</subject><subject>Titanium - pharmacology</subject><subject>Transplants & implants</subject><issn>1071-2690</issn><issn>1543-706X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1rFTEUhgdRbK3-ARcyIIKb2HPyMUmWUuoHVgpFwV3IZDKXXO5MrklGbv99Y6dqcdFsknCe983JeZvmJcI7BJCnGbGjHQEKBIBzTuSj5hgFZ0RC9-NxPYNEQjsNR82znLdQl8buaXPEKJXANB43h6_BpWiTa-MhDLaEOLd5SaN1vo1jW0Kxc1imNkz7nZ1LbvcpTrHUYi4-bvwcXDuEcfTJzyWs-v66ta6EX_U2b9rzqy94SskUrggqKsllFaZweN48Ge0u-xd3-0nz_cP5t7NP5OLy4-ez9xfEcRCFcMWtVk5Q5JIrKRXorvedkkPPUQ92cNoKp2AUVEhPez46HIXCwSHDXlJ20rxdfWvjPxefi5lCdn5Xf-Pjkg1lSgHUgaiKvv4P3cYlzbU7QzlS7DiTXaXoStW55Zz8aPYpTDZdGwTzOxez5mJqLuY2FyOr6NWd9dJPfvgr-RNEBdgK5FqaNz79e_tB2zeraptLTPcboawquKBaaMnYDeRno48</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Liu, Liu</creator><creator>Zeng, Da</creator><creator>Chen, Yanwen</creator><creator>Zhou, Junbo</creator><creator>Liao, Yunyang</creator><creator>Shi, Bin</creator><general>Springer Science & Business Media LLC</general><general>Springer US</general><general>Society for In Vitro Biology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20200401</creationdate><title>Microarc oxidation surface of titanium implants promote osteogenic differentiation by activating ERK1/2-miR-1827-Osterix</title><author>Liu, Liu ; Zeng, Da ; Chen, Yanwen ; Zhou, Junbo ; Liao, Yunyang ; Shi, Bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-484a98c5214748778096be687db419dadc9a5c80f5257e2b4fc1f581dc131b723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adipogenesis - drug effects</topic><topic>Adipogenesis - genetics</topic><topic>Animal Genetics and Genomics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical materials</topic><topic>BIOTECHNOLOGY</topic><topic>Bone implants</topic><topic>Bone marrow</topic><topic>Cell Biology</topic><topic>Cell Culture</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Differentiation - genetics</topic><topic>Coating</topic><topic>Coatings</topic><topic>Developmental Biology</topic><topic>Differentiation (biology)</topic><topic>Extracellular signal-regulated kinase</topic><topic>Extracellular Signal-Regulated MAP Kinases - metabolism</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>MAP kinase</topic><topic>Mesenchymal stem cells</topic><topic>Mesenchyme</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Osteogenesis</topic><topic>Osteogenesis - drug effects</topic><topic>Osteogenesis - genetics</topic><topic>Osteolysis</topic><topic>Oxidation</topic><topic>Oxidation-Reduction</topic><topic>p38 Mitogen-Activated Protein Kinases - metabolism</topic><topic>Prostheses and Implants</topic><topic>Signal transduction</topic><topic>Sp7 Transcription Factor - metabolism</topic><topic>Stem Cells</topic><topic>Surgical implants</topic><topic>Titanium</topic><topic>Titanium - pharmacology</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Liu</creatorcontrib><creatorcontrib>Zeng, Da</creatorcontrib><creatorcontrib>Chen, Yanwen</creatorcontrib><creatorcontrib>Zhou, Junbo</creatorcontrib><creatorcontrib>Liao, Yunyang</creatorcontrib><creatorcontrib>Shi, Bin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Docstoc</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>In vitro cellular & developmental biology. Animal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Liu</au><au>Zeng, Da</au><au>Chen, Yanwen</au><au>Zhou, Junbo</au><au>Liao, Yunyang</au><au>Shi, Bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microarc oxidation surface of titanium implants promote osteogenic differentiation by activating ERK1/2-miR-1827-Osterix</atitle><jtitle>In vitro cellular & developmental biology. Animal</jtitle><stitle>In Vitro Cell.Dev.Biol.-Animal</stitle><addtitle>In Vitro Cell Dev Biol Anim</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>56</volume><issue>4</issue><spage>296</spage><epage>306</epage><pages>296-306</pages><issn>1071-2690</issn><eissn>1543-706X</eissn><abstract>There has been a constant requirement from the clinic to develop biomédical titanium (Ti) implants with high osteogenic ability. In this study, we clarified a novel mechanism of how MAO (microarc oxidation) coating of Ti implants facilitates osteogenic differentiation of human bone marrow mesenchymal stem cells (hB-MSCs) by activating ERKl/2-miR-1827-Osterix signaling pathway in vitro. MAO surface of titanium implant was more favorable to promote osteogenic differentiation than SLA and AOS coating. Besides, titanium implants regulated hB-MSCs osteogenesis through the p38 MAPK pathway and ERK1/2 might be the most efficient target. Furthermore, MAO coating induced osteogenic differentiation though ERK1/2-miR-1827 pathway. Finally, we verified miR-1827 regulated osteogenic differentiation partially through Osterix. Our study reveals novel insights that MAO surface of titanium implant is a prior choice for biomédical trial and for its use in periprosthetic osteolysis (PIO) treatment in an evidence-based rationale.</abstract><cop>New York</cop><pub>Springer Science & Business Media LLC</pub><pmid>32270391</pmid><doi>10.1007/s11626-020-00444-7</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1071-2690 |
| ispartof | In vitro cellular & developmental biology. Animal, 2020-04, Vol.56 (4), p.296-306 |
| issn | 1071-2690 1543-706X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2388003228 |
| source | JSTOR Archive Collection A-Z Listing; MEDLINE; Springer Online Journals Complete |
| subjects | Adipogenesis - drug effects Adipogenesis - genetics Animal Genetics and Genomics Biomedical and Life Sciences Biomedical materials BIOTECHNOLOGY Bone implants Bone marrow Cell Biology Cell Culture Cell Differentiation - drug effects Cell Differentiation - genetics Coating Coatings Developmental Biology Differentiation (biology) Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Humans Life Sciences MAP kinase Mesenchymal stem cells Mesenchyme MicroRNAs - genetics MicroRNAs - metabolism Osteogenesis Osteogenesis - drug effects Osteogenesis - genetics Osteolysis Oxidation Oxidation-Reduction p38 Mitogen-Activated Protein Kinases - metabolism Prostheses and Implants Signal transduction Sp7 Transcription Factor - metabolism Stem Cells Surgical implants Titanium Titanium - pharmacology Transplants & implants |
| title | Microarc oxidation surface of titanium implants promote osteogenic differentiation by activating ERK1/2-miR-1827-Osterix |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T13%3A54%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Microarc%20oxidation%20surface%20of%20titanium%20implants%20promote%20osteogenic%20differentiation%20by%20activating%20ERK1/2-miR-1827-Osterix&rft.jtitle=In%20vitro%20cellular%20&%20developmental%20biology.%20Animal&rft.au=Liu,%20Liu&rft.date=2020-04-01&rft.volume=56&rft.issue=4&rft.spage=296&rft.epage=306&rft.pages=296-306&rft.issn=1071-2690&rft.eissn=1543-706X&rft_id=info:doi/10.1007/s11626-020-00444-7&rft_dat=%3Cjstor_proqu%3E45295973%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2412164376&rft_id=info:pmid/32270391&rft_jstor_id=45295973&rfr_iscdi=true |