Why Warburg Works: Lactate Controls Immune Evasion through GPR81

Lactate accumulation in tumors—a hallmark of the Warburg effect—has recently been shown to regulate cancer cell metabolism and survival through autocrine activation of GPR81. Now, Brown et al. (2020) demonstrate that lactate surprisingly also controls immune evasion through paracrine activation of G...

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Veröffentlicht in:	Cell metabolism 2020-04, Vol.31 (4), p.666-668
Hauptverfasser:	Lundø, Kathrine, Trauelsen, Mette, Pedersen, Stine F., Schwartz, Thue W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen-Presenting Cells Breast Neoplasms Humans Immune Evasion Lactic Acid Receptors, G-Protein-Coupled Tumor Microenvironment
Online-Zugang:	Volltext
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Zusammenfassung:	Lactate accumulation in tumors—a hallmark of the Warburg effect—has recently been shown to regulate cancer cell metabolism and survival through autocrine activation of GPR81. Now, Brown et al. (2020) demonstrate that lactate surprisingly also controls immune evasion through paracrine activation of GPR81 on stromal dendritic cells. Lactate accumulation in tumors—a hallmark of the Warburg effect—has recently been shown to regulate cancer cell metabolism and survival through autocrine activation of GPR81. Now, Brown et al. (2020) demonstrate that lactate surprisingly also controls immune evasion through paracrine activation of GPR81 on stromal dendritic cells.
ISSN:	1550-4131 1932-7420
DOI:	10.1016/j.cmet.2020.03.001