The RESOLUTE consortium: unlocking SLC transporters for drug discovery

The Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and produce data sets to de-orphanize transporters in the solute carrier protein (SLC) superfamily, thereby lowering the barrier for the scientific community to explore SLCs as an attractive drug target class. The I...

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Veröffentlicht in:	Nature reviews. Drug discovery 2020-07, Vol.19 (7), p.429-430
Hauptverfasser:	Superti-Furga, Giulio, Lackner, Daniel, Wiedmer, Tabea, Ingles-Prieto, Alvaro, Barbosa, Barbara, Girardi, Enrico, Goldmann, Ulrich, Gürtl, Bettina, Klavins, Kristaps, Klimek, Christoph, Lindinger, Sabrina, Liñeiro-Retes, Eva, Müller, André C., Onstein, Svenja, Redinger, Gregor, Reil, Daniela, Sedlyarov, Vitaly, Wolf, Gernot, Crawford, Matthew, Everley, Robert, Hepworth, David, Noell, Stephen, Piotrowski, Mary, Stanton, Robert, Zhang, Hui, Corallino, Salvatore, Faedo, Andrea, Insidioso, Maria, Maresca, Giovanna, Redaelli, Loredana, Sassone, Francesca, Scarabottolo, Lia, Stucchi, Michela, Tarroni, Paola, Tremolada, Sara, Batoulis, Helena, Becker, Andreas, Bender, Eckhard, Chang, Yung-Ning, Ehrmann, Alexander, Müller-Fahrnow, Anke, Pütter, Vera, Zindel, Diana, Hamilton, Bradford, Lenter, Martin, Santacruz, Diana, Viollet, Coralie, Whitehurst, Charles, Johnsson, Kai, Leippe, Philipp, Baumgarten, Birgit, Chang, Lena, Ibig, Yvonne, Pfeifer, Martin, Reinhardt, Jürgen, Schönbett, Julian, Selzer, Paul, Seuwen, Klaus, Bettembourg, Charles, Biton, Bruno, Czech, Jörg, de Foucauld, Hélène, Didier, Michel, Licher, Thomas, Mikol, Vincent, Pommereau, Antje, Puech, Frédéric, Yaligara, Veeranagouda, Edwards, Aled, Bongers, Brandon J., Heitman, Laura H., IJzerman, Ad P., Sijben, Huub J., van Westen, Gerard J.P., Grixti, Justine, Kell, Douglas B., Mughal, Farah, Swainston, Neil, Wright-Muelas, Marina, Burgess-Brown, Nicola, Carpenter, Liz, Dürr, Katharina, Hansen, Jesper, Scacioc, Andreea, Colas, Claire, Digles, Daniela, Ecker, Gerhard, Füzi, Barbara, Gamsjäger, Viktoria, Grandits, Melanie, Martini, Riccardo, Troger, Florentina, Altermatt, Patrick, Doucerain, Cédric, Dürrenberger, Franz, Manolova, Vania, Steck, Anna-Lena, Sundström, Hanna, Wilhelm, Maria, Steppan, Claire M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alliances Biological Transport Comment Consortia Drug discovery Drug Discovery - methods Drugs Humans Pharmaceutical Preparations - metabolism Solute Carrier Proteins - metabolism Type 2 diabetes
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Zusammenfassung:	The Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and produce data sets to de-orphanize transporters in the solute carrier protein (SLC) superfamily, thereby lowering the barrier for the scientific community to explore SLCs as an attractive drug target class. The Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and produce data sets to de-orphanize transporters in the solute carrier protein (SLC) superfamily, thereby lowering the barrier for the scientific community to explore SLCs as an attractive drug target class.
ISSN:	1474-1776 1474-1784
DOI:	10.1038/d41573-020-00056-6