Frequency and Correlates of Acute Dystonic Reactions After Antipsychotic Initiation in 441 Children and Adolescents

To determine the incidence of acute dystonic reactions (ADRs) and risk factors for ADRs in children and adolescents treated with antipsychotics. This was a retrospective chart review-based cohort study of consecutive patients who attended a university hospital's child and adolescent psychiatry...

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Veröffentlicht in:Journal of child and adolescent psychopharmacology 2020-07, Vol.30 (6), p.366-375
Hauptverfasser: Tural Hesapcioglu, Selma, Ceylan, Mehmet Fatih, Kandemir, Gözde, Kasak, Meryem, Sen, Cansu Pınar, Correll, Christoph U
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Sprache:eng
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Zusammenfassung:To determine the incidence of acute dystonic reactions (ADRs) and risk factors for ADRs in children and adolescents treated with antipsychotics. This was a retrospective chart review-based cohort study of consecutive patients who attended a university hospital's child and adolescent psychiatry department between 2015 and 2017 and who were treated with antipsychotics and had at least two follow-up visits. Thirty of 441 patients (6.8%) 4-19 years of age who were treated with antipsychotics for conduct disorders (21.5%), attention-deficit/hyperactivity disorder (13.2%) and, irritability and aggression that accompanied intellectual disability (12.9%) and followed for 99.5 ± 223.3 (median: 34) days developed ADRs. ADRs developed in 11/391 patients (2.8%) treated with one antipsychotic and 19/50 patients (38.0%) treated with two antipsychotics (  
ISSN:1044-5463
1557-8992
DOI:10.1089/cap.2019.0123